Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. - Wikidata - wikimedia - TriplyDB

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles.

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles.

http://www.wikidata.org/entity/Q37069801

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Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease.Designing siRNA that distinguish between genes that differ by a single nucleotide Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi.Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype.RNA interference and nonviral targeted gene therapy of experimental brain cancer Infrared multiphoton dissociation of small-interfering RNA anions and cations Self-assembled lipid nanomedicines for siRNA tumor targeting.Efficient allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi.Unlocking the potential of the human genome with RNA interference.siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.Viral-based modelling and correction of neurodegenerative diseases by RNA interference.RNAi therapeutics: principles, prospects and challenges.New type of BACE1 siRNA delivery to cells.Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells Genomic characterization of Alzheimer's disease and genotype-related phenotypic analysis of biological markers in dementia.Allele-specific RNA interference for neurological disease.Silencing neurodegenerative disease: bringing RNA interference to the clinic.Modification of globin gene expression by RNA targeting strategies.Current experimental therapy for Alzheimer's disease Novel therapeutic strategies for the treatment of protein-misfolding diseases.Modulating the expression of disease genes with RNA-based therapy.Recent advances in RNA interference therapeutics for CNS diseases.Applying small RNA molecules to the directed treatment of human diseases: realizing the potential.Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics.Disease-causing allele-specific silencing by RNA interference.Alzheimer's disease: presence and role of microRNAs.RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity.Lipid-based systemic delivery of siRNA.The complex world of oligodendroglial differentiation inhibitors.RNAi: a potential new class of therapeutic for human genetic disease.Drug discovery using the regulation of gene expression.Advances in the therapy of Alzheimer's disease: targeting amyloid beta and tau and perspectives for the future.microRNAs and Neurodegenerative Diseases.siRNA against presenilin 1 (PS1) down regulates amyloid β42 production in IMR-32 cells.Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2A.Rational design and in vitro and in vivo delivery of Dicer substrate siRNA.Regulating MHC expression for cellular therapeutics.Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.

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Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles.

http://www.wikidata.org/entity/Q37069801

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 30 January 2004

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Targeting Alzheimer's disease ...... for silencing mutant alleles.

@en

Targeting Alzheimer's disease ...... for silencing mutant alleles.

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type

label

Targeting Alzheimer's disease ...... for silencing mutant alleles.

@en

Targeting Alzheimer's disease ...... for silencing mutant alleles.

@nl

prefLabel

Targeting Alzheimer's disease ...... for silencing mutant alleles.

@en

Targeting Alzheimer's disease ...... for silencing mutant alleles.

@nl

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Targeting Alzheimer's disease ...... for silencing mutant alleles.

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Beverly L Davidson

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Cynthia M Gouvion

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Henry L Paulson

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Victor M Miller

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P2860

Allele-specific silencing of a pathogenic mutant acetylcholine receptor subunit by RNA interference

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

Asymmetry in the assembly of the RNAi enzyme complex

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

siRNAs can function as miRNAs

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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661-668

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scholarly article

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10.1093/NAR/GKH208

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14754988

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Alzheimer's disease

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373334

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