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Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesisTranslocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1An overview of sphingolipid metabolism: from synthesis to breakdownTargeting Insulin-Like Growth Factor Binding Protein-3 Signaling in Triple-Negative Breast CancerSphingosine-1-phosphate in chronic intestinal inflammation and cancerEvolving concepts in cancer therapy through targeting sphingolipid metabolismSTAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancerExport of sphingosine-1-phosphate and cancer progressionSphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesisSphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditionsDrugging sphingosine kinases.A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophagesSphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.The impact of sphingosine kinase-1 in head and neck cancer.Re-configuration of sphingolipid metabolism by oncogenic transformation.Sphingosine kinase 1 expression enhances colon tumor growth.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Sphingosine kinase 1 in cancer.S1P metabolism in cancer and other pathological conditions.Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinaseTargeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.Roles of sphingosine 1-phosphate on tumorigenesisTargeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2Sphingolipid metabolites in inflammatory disease.Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasiaTumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind HydeA selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.Defining a role for sphingosine kinase 1 in p53-dependent tumors.Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer CellsA role of sphingosine kinase 1 in head and neck carcinogenesisLoss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Role for sphingosine kinase 1 in colon carcinogenesis.
@en
Role for sphingosine kinase 1 in colon carcinogenesis.
@nl
type
label
Role for sphingosine kinase 1 in colon carcinogenesis.
@en
Role for sphingosine kinase 1 in colon carcinogenesis.
@nl
prefLabel
Role for sphingosine kinase 1 in colon carcinogenesis.
@en
Role for sphingosine kinase 1 in colon carcinogenesis.
@nl
P2093
P2860
P356
P1433
P1476
Role for sphingosine kinase 1 in colon carcinogenesis
@en
P2093
Andre Uflacker
Jacek Bielawski
Masae Okumura
Samer Maalouf
Tatsuya Kaneshiro
Toshihiko Kawamori
P2860
P304
P356
10.1096/FJ.08-117572
P407
P577
2008-09-29T00:00:00Z