Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation
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Integrated physiology and systems biology of PPARαRegulation of peripheral metabolism by substrate partitioning in the brain.Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondriaAdaptation of phenylalanine and tyrosine catabolic pathway to hibernation in batsMetabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammationFrom raw materials to validated system: the construction of a genomic library and microarray to interpret systemic perturbations in Northern bobwhiteMechanism for prevention of alcohol-induced liver injury by dietary methyl donors.Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice.Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesisThe Role of PPARα Activation in Liver and Muscle.Metabolic profiling of muscle contraction in lean compared with obese rodents.The molecular and metabolic influence of long term agmatine consumptionA Review of Mitochondrial-derived Fatty Acids in Epigenetic Regulation of Obesity and Type 2 DiabetesLiver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding.Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy.Fish oil and the pan-PPAR agonist tetradecylthioacetic acid affect the amino acid and carnitine metabolism in rats.NMR and LC/MS-based global metabolomics to identify serum biomarkers differentiating hepatocellular carcinoma from liver cirrhosis.Metabolites related to gut bacterial metabolism, peroxisome proliferator-activated receptor-alpha activation, and insulin sensitivity are associated with physical function in functionally-limited older adultsDietary quercetin supplementation in mice increases skeletal muscle PGC1α expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner.Nutrition and metabolic correlates of obesity and inflammation: clinical considerations.Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids.Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioningDeletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouseMultiparity leads to obesity and inflammation in mothers and obesity in male offspring.Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity.The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.The inflammation highway: metabolism accelerates inflammatory traffic in obesity.Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during ExerciseEctopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice.Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research.Peroxisome proliferator activated receptor α ligands as anticancer drugs targeting mitochondrial metabolismImplications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancerMeasuring mitochondrial respiration in intact single muscle fibers.Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic controlMetabolomics applied to diabetes research: moving from information to knowledge
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P2860
Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Metabolic profiling of PPARalp ...... oral carnitine supplementation
@en
Metabolic profiling of PPARalp ...... ral carnitine supplementation.
@nl
type
label
Metabolic profiling of PPARalp ...... oral carnitine supplementation
@en
Metabolic profiling of PPARalp ...... ral carnitine supplementation.
@nl
prefLabel
Metabolic profiling of PPARalp ...... oral carnitine supplementation
@en
Metabolic profiling of PPARalp ...... ral carnitine supplementation.
@nl
P2093
P2860
P356
P1433
P1476
Metabolic profiling of PPARalp ...... oral carnitine supplementation
@en
P2093
Michael J Muehlbauer
Olga R Ilkayeva
Robert C Noland
Robert D Stevens
Timothy R Koves
Weibing Xing
P2860
P304
P356
10.1096/FJ.08-119420
P407
P577
2008-10-22T00:00:00Z