Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein - Wikidata - wikimedia - TriplyDB

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

http://www.wikidata.org/entity/Q37073031

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The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7 Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism Systematic analysis and nomenclature of mammalian F-box proteins Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice Control of cell growth by the SCF and APC/C ubiquitin ligases Endoreplication: polyploidy with purpose Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1 Endoreplication Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases Fbxw7 controls angiogenesis by regulating endothelial Notch activity FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines Histone deacetylase activity selectively regulates notch-mediated smooth muscle differentiation in human vascular cells.The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.Turn It Down a Notch Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.Aberrant regulation of FBW7 in cancer.Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.Accessing key steps of human tumor progression in vivo by using an avian embryo model.FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma.The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility Cullins and cancer.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.Multiple novel alternative splicing forms of FBXW7α have a translational modulatory function and show specific alteration in human cancer.Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease Roles of F-box proteins in cancer

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Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

http://www.wikidata.org/entity/Q37073031

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bilimsel makale

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scientific article published on 06 February 2004

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Defective cardiovascular devel ...... lacking the Fbw7 F-box protein

@en

Defective cardiovascular devel ...... acking the Fbw7 F-box protein.

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type

label

Defective cardiovascular devel ...... lacking the Fbw7 F-box protein

@en

Defective cardiovascular devel ...... acking the Fbw7 F-box protein.

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prefLabel

Defective cardiovascular devel ...... lacking the Fbw7 F-box protein

@en

Defective cardiovascular devel ...... acking the Fbw7 F-box protein.

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PNAS.0307875101

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Proceedings of the National Academy of Sciences of the United States of America

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Defective cardiovascular devel ...... lacking the Fbw7 F-box protein

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Kathleen Mahon

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Mamie Li

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Michael T Tetzlaff

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Milton Finegold

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Pumin Zhang

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Robert J Schwartz

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Stephen J Elledge

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Wei Yu

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P2860

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

A family of mammalian F-box proteins

Notch receptors and hematopoiesis

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

The Notch1 receptor is cleaved constitutively by a furin-like convertase

Cyclins in breast cancer: too much of a good thing.

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3338-3345

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scholarly article

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10.1073/PNAS.0307875101

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10

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101

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Jeffrey W. Harper

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2004-02-06T00:00:00Z

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8882751

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14766969

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Aparato circulatorio

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373463

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