The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation - Wikidata - wikimedia - TriplyDB

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

http://www.wikidata.org/entity/Q34835596

about

The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7 Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells Systematic analysis and nomenclature of mammalian F-box proteins MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7 The histone deacetylase SIRT2 stabilizes Myc oncoproteins Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming Multiple Functions of the Eya Phosphotyrosine Phosphatase The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma Molecular functions of genes related to grain shape in rice Targeting the ubiquitin pathway for cancer treatment Synthetic lethal screens as a means to understand and treat MYC-driven cancers Animal models of colorectal cancer FBW7-mediated ubiquitination and degradation of KLF5 Mitotic and mitogenic Wnt signalling Prolyl isomerase Pin1 in cancer O-GlcNAcylation and Metabolic Reprograming in Cancer SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.The role of aberrant proteolysis in lymphomagenesis Dysregulation of ubiquitin ligases in cancer CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60 The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

http://www.wikidata.org/entity/Q34835596

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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name

The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

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The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

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The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

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The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

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The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

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The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

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The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

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The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

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Proceedings of the National Academy of Sciences of the United States of America

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The Fbw7 tumor suppressor regu ...... dent c-Myc protein degradation

@en

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Amir Orian

http://www.w3.org/2001/XMLSchema#string

Bruce E Clurman

http://www.w3.org/2001/XMLSchema#string

J Wade Harper

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Jianping Jin

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Jonathan E Grim

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Robert N Eisenman

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P2860

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Role of the F-box protein Skp2 in lymphomagenesis

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

hCDC4 gene mutations in endometrial cancer

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10.1073/PNAS.0402770101

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24

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101

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15150404

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phosphorylation

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428477

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