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alpha- and gamma-Protocadherins negatively regulate PYK2

alpha- and gamma-Protocadherins negatively regulate PYK2

http://www.wikidata.org/entity/Q37075312

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Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret Combinatorial homophilic interaction between gamma-protocadherin multimers greatly expands the molecular diversity of cell adhesion Proteolytic processing of protocadherin proteins requires endocytosis Clustered protocadherins A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway Protocadherins and hypothalamic development: do they play an unappreciated role?γ-protocadherins are enriched and transported in specialized vesicles associated with the secretory pathway in neurons Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor.Proteomics analysis reveals overlapping functions of clustered protocadherins.PDCD10/CCM3 acts downstream of {gamma}-protocadherins to regulate neuronal survival.Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.Nuclear signaling from cadherin adhesion complexes Protein Kinase C Phosphorylation of a γ-Protocadherin C-terminal Lipid Binding Domain Regulates Focal Adhesion Kinase Inhibition and Dendrite Arborization.Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems Molecular and functional interaction between protocadherin-γC5 and GABAA receptors.PiggyBac transgenic strategies in the developing chicken spinal cord Protocadherins, not prototypical: a complex tale of their interactions, expression, and functions.Genetic basis of neuronal individuality in the mammalian brain.Sorting out a promiscuous superfamily: towards cadherin connectomics.Constitutively expressed Protocadherin-α regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic region Protocadherins branch out: Multiple roles in dendrite development.Regulation of Wnt signaling by protocadherins.Regulation of neural circuit formation by protocadherins.Multiple protocadherins are expressed in brain microvascular endothelial cells and might play a role in tight junction protein regulation.Aberrant expression and functions of protocadherins in human malignant tumors.Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase.Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.Homophilic Protocadherin Cell-Cell Interactions Promote Dendrite Complexity.SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes.Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.The clustered protocadherins Pcdhα and Pcdhγ form a heteromeric complex in zebrafish.γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway.Protocadherin-αC2 is required for diffuse projections of serotonergic axons.NIPBL+/- haploinsufficiency reveals a constellation of transcriptome disruptions in the pluripotent and cardiac states.Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

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P2860

alpha- and gamma-Protocadherins negatively regulate PYK2

http://www.wikidata.org/entity/Q37075312

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on December 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

alpha- and gamma-Protocadherins negatively regulate PYK2

@en

alpha- and gamma-Protocadherins negatively regulate PYK2.

@nl

type

label

alpha- and gamma-Protocadherins negatively regulate PYK2

@en

alpha- and gamma-Protocadherins negatively regulate PYK2.

@nl

prefLabel

alpha- and gamma-Protocadherins negatively regulate PYK2

@en

alpha- and gamma-Protocadherins negatively regulate PYK2.

@nl

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Journal of Biological Chemistry

P1476

alpha- and gamma-Protocadherins negatively regulate PYK2

@en

P2093

Chengyi Lin

http://www.w3.org/2001/XMLSchema#string

Jian Chen

http://www.w3.org/2001/XMLSchema#string

Meng-Hsuan Han

http://www.w3.org/2001/XMLSchema#string

Shuxia Meng

http://www.w3.org/2001/XMLSchema#string

Xiaozhong Wang

http://www.w3.org/2001/XMLSchema#string

Yanyan Lu

http://www.w3.org/2001/XMLSchema#string

P2860

A striking organization of a large family of human neural cadherin-like cell adhesion genes

Integrin-regulated FAK-Src signaling in normal and cancer cells

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions

Structural basis for the autoinhibition of focal adhesion kinase

Suppression of Pyk2 kinase and cellular activities by FIP200

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity

P304

2880-2890

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scholarly article

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10.1074/JBC.M807417200

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P407

P433

5

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284

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2008-12-01T00:00:00Z

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19047047

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2631960

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