Defects in retinal pigment epithelium cell proliferation and retinal attachment in mutant mice with p27(Kip1) gene ablation
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The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells.PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice.Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice.Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27Kip1.Mature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss.The new paradigm: retinal pigment epithelium cells generated from embryonic or induced pluripotent stem cells.Corneal endothelial cells possess an elaborate multipolar shape to maximize the basolateral to apical membrane areap27(KIP1) loss promotes proliferation and phagocytosis but prevents epithelial-mesenchymal transition in RPE cells after photoreceptor damage.Retinal pigment epithelium development, plasticity, and tissue homeostasis.Cell type-specific effects of p27KIP1 loss on retinal development.PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation.
P2860
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P2860
Defects in retinal pigment epithelium cell proliferation and retinal attachment in mutant mice with p27(Kip1) gene ablation
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 February 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Defects in retinal pigment epi ...... chment in mutant mice with p27
@nl
Defects in retinal pigment epi ...... e with p27(Kip1) gene ablation
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type
label
Defects in retinal pigment epi ...... chment in mutant mice with p27
@nl
Defects in retinal pigment epi ...... e with p27(Kip1) gene ablation
@en
prefLabel
Defects in retinal pigment epi ...... chment in mutant mice with p27
@nl
Defects in retinal pigment epi ...... e with p27(Kip1) gene ablation
@en
P2093
P2860
P1433
P1476
Defects in retinal pigment epi ...... e with p27(Kip1) gene ablation
@en
P2093
Dennis M Defoe
Edward M Levine
Jingru Sun
Lorrie B S Adams
Sarah N Wisecarver
P2860
P304
P577
2007-02-27T00:00:00Z