Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function
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Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunityReciprocal crosstalk between dendritic cells and natural killer cells under the effects of PGE2 in immunity and immunopathologyMultiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancerE-type prostanoid receptor 4 (EP4) in disease and therapyProstaglandin E2 and T cells: friends or foes?Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparities.Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunctionHuman breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity.Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer.Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGFA prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis.Gastric cancer cells inhibit natural killer cell proliferation and induce apoptosis via prostaglandin E2.Prostaglandin E2 EP receptors as therapeutic targets in breast cancer.Prostaglandin E(2) (PGE (2)) suppresses natural killer cell function primarily through the PGE(2) receptor EP4Modulation of host natural killer cell functions in breast cancer via prostaglandin E2 receptors EP2 and EP4Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy.Surgery as a double-edged sword: a clinically feasible approach to overcome the metastasis-promoting effects of surgery by blunting stress and prostaglandin responses.Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties.Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model.Prostaglandin E2 produced following infection with Theiler's virus promotes the pathogenesis of demyelinating disease.The prognostic value of regulatory T cells infiltration in HER2-enriched breast cancer microenvironment.
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Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 September 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Antagonism of the prostaglandi ...... tasis and enhances NK function
@en
Antagonism of the prostaglandi ...... asis and enhances NK function.
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type
label
Antagonism of the prostaglandi ...... tasis and enhances NK function
@en
Antagonism of the prostaglandi ...... asis and enhances NK function.
@nl
prefLabel
Antagonism of the prostaglandi ...... tasis and enhances NK function
@en
Antagonism of the prostaglandi ...... asis and enhances NK function.
@nl
P2093
P2860
P1476
Antagonism of the prostaglandi ...... tasis and enhances NK function
@en
P2093
Amy M Fulton
Namita Kundu
Olga Goloubeva
Suzanne Ostrand-Rosenberg
Xinrong Ma
P2860
P2888
P304
P356
10.1007/S10549-008-0180-5
P407
P577
2008-09-16T00:00:00Z