Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
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Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system.Chemical probes of endocannabinoid metabolismA lipid gate for the peripheral control of painA Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide HydrolaseElevating endocannabinoid levels: pharmacological strategies and potential therapeutic applicationsOmeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain modelPeripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptiveRole of Cannabinoids in Gastrointestinal Mucosal Defense and InflammationPeripheral gating of pain signals by endogenous lipid mediators.Acute Δ(9)-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in miceSynthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain modelsCombined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models.Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides.Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in miceEndocannabinoid signaling at the periphery: 50 years after THC.Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic propertiesPharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrierPotent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes.Endogenous N-acyl taurines regulate skin wound healing.Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain.Anandamide in primary sensory neurons: too much of a good thing?No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids.The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.COX inhibitors: a patent review (2011 - 2014).Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine.Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitorThe endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice.An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis.
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Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 March 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.
@en
Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.
@nl
type
label
Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.
@en
Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.
@nl
prefLabel
Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.
@en
Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.
@nl
P2093
P2860
P1476
Peripheral FAAH inhibition cau ...... hacin-induced gastric lesions.
@en
P2093
Andrea Armirotti
Angelo Reggiani
Daniele Piomelli
Giampiero Colombano
Guillermo Moreno-Sanz
Oscar Sasso
Rita Scarpelli
Rosalia Bertorelli
Tiziano Bandiera
P2860
P304
P356
10.1016/J.PHRS.2012.02.012
P577
2012-03-07T00:00:00Z