Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.
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Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseasesFYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transportA novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagyHuman papillomavirus infection is inhibited by host autophagy in primary human keratinocytesThe small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infectionPI(5)P regulates autophagosome biogenesisAutophagy signal transduction by ATG proteins: from hierarchies to networksMicroRNA-mediated autophagic signaling networks and cancer chemoresistanceAutophagy and neurodegenerationMicroRNAs in autophagy and their emerging roles in crosstalk with apoptosisEmerging strategies to effectively target autophagy in cancerBeclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complexSpreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegansRegulation of autophagy by the Rab GTPase networkThe Beclin 1-VPS34 complex--at the crossroads of autophagy and beyondAutophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infectionsInvolvement of Beclin 1 in engulfment of apoptotic cellsEhrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinaseActivity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT PathwayTBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome MaturationNeuronal Mitophagy in Neurodegenerative DiseasesPlasma membrane contributes to the formation of pre-autophagosomal structuresBiochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.Internalized gap junctions are degraded by autophagyA novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid dropletsConformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.Role of class III phosphatidylinositol 3-kinase during programmed nuclear death of Tetrahymena thermophila.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cellsAlzheimer's disease: insights from Drosophila melanogaster models.Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.The nutrient stress-induced small GTPase Rab5 contributes to the activation of vesicle trafficking and vacuolar activity.The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy.A Vps21 endocytic module regulates autophagy.The role of chaperone-mediated autophagy in huntingtin degradation.Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species productionRegulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.α-Synuclein impairs macroautophagy: implications for Parkinson's disease.
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Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 April 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Rab5 modulates aggregation and ...... models of Huntington disease.
@en
Rab5 modulates aggregation and ...... models of Huntington disease.
@nl
type
label
Rab5 modulates aggregation and ...... models of Huntington disease.
@en
Rab5 modulates aggregation and ...... models of Huntington disease.
@nl
prefLabel
Rab5 modulates aggregation and ...... models of Huntington disease.
@en
Rab5 modulates aggregation and ...... models of Huntington disease.
@nl
P2093
P2860
P356
P1476
Rab5 modulates aggregation and ...... models of Huntington disease.
@en
P2093
Brinda Ravikumar
Cahir J O'Kane
David C Rubinsztein
Sara Imarisio
Sovan Sarkar
P2860
P304
P356
10.1242/JCS.025726
P407
P577
2008-04-22T00:00:00Z