Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. - Wikidata - wikimedia - TriplyDB

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.

http://www.wikidata.org/entity/Q37088889

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Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?Genomic approaches to identifying targets for treating β hemoglobinopathies Anemia: progress in molecular mechanisms and therapies Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations.Global genetic architecture of an erythroid quantitative trait locus, HMIP-2 The power of meta-analysis in genome-wide association studies Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels.Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia.SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.Variation in MSRA modifies risk of neonatal intestinal obstruction in cystic fibrosis.Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?Identifying causal variants at loci with multiple signals of association Quantifying missing heritability at known GWAS loci.Translational genomics. Clues from the resilient.Finding missing heritability in less significant Loci and allelic heterogeneity: genetic variation in human height.Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.The genetics of hemoglobin A2 regulation in sickle cell anemia A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer.Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence Genotyping of BCL11A and HBS1L-MYB SNPs associated with fetal haemoglobin levels: a SNaPshot minisequencing approach Fetal hemoglobin in sickle cell anemia BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia.A functional element necessary for fetal hemoglobin silencing Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association A genetic score for the prediction of beta-thalassemia severity.Variants in genetic modifiers of β-thalassemia can help to predict the major or intermedia type of the disease Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries.Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development 2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment

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Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.

http://www.wikidata.org/entity/Q37088889

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Fine-mapping at three loci kno ...... additional genetic variation.

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Fine-mapping at three loci kno ...... additional genetic variation.

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type

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Fine-mapping at three loci kno ...... additional genetic variation.

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Fine-mapping at three loci kno ...... additional genetic variation.

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prefLabel

Fine-mapping at three loci kno ...... additional genetic variation.

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Fine-mapping at three loci kno ...... additional genetic variation.

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Nature Genetics

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Fine-mapping at three loci kno ...... additional genetic variation.

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Cameron D Palmer

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Geneviève Galarneau

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Guillaume Lettre

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Joel N Hirschhorn

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Stuart H Orkin

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Vijay G Sankaran

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P2860

Finding the missing heritability of complex diseases

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

Developmental and species-divergent globin switching are driven by BCL11A

A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E

Rare variants create synthetic genome-wide associations

Heritability of cardiovascular and personality traits in 6,148 Sardinians

Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

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1049-1051

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10.1038/NG.707

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21057501

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3740938

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