Amelioration of Sardinian beta0 thalassemia by genetic modifiers. - Wikidata - wikimedia - TriplyDB

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

http://www.wikidata.org/entity/Q34079112

about

Customizing the genome as therapy for the β-hemoglobinopathies Genomic approaches to identifying targets for treating β hemoglobinopathies Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies Global genetic architecture of an erythroid quantitative trait locus, HMIP-2 Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin.Update on fetal hemoglobin gene regulation in hemoglobinopathies A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression A genetic score for the prediction of beta-thalassemia severity.Variants in genetic modifiers of β-thalassemia can help to predict the major or intermedia type of the disease Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans.α-Globin as a molecular target in the treatment of β-thalassemia Genetic modifiers of β-thalassemia and clinical severity as assessed by age at first transfusion.The switch from fetal to adult hemoglobin Pathophysiology and Clinical Manifestations of the β-Thalassemias.The prevention of thalassemia.Seventy-five genetic loci influencing the human red blood cell Advances in understanding erythropoiesis: evolving perspectives Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders Non-transfusion-dependent thalassemias.Regulation of the fetal hemoglobin silencing factor BCL11A.Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.Guidelines on Beta-thalassemia major - regular blood transfusion therapy: Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular: project guidelines: Associação Médica Brasileira - 2016.Beta-thalassemia.Advances in the understanding of haemoglobin switching.Modifier genes in Mendelian disorders: the example of hemoglobin disorders.Optimal management of β thalassaemia intermedia.Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis.Diagnosis and prevention of thalassemia.Individualizing fetal hemoglobin augmenting therapy for β-type hemoglobinopathies patients.Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches.An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.Molecular basis of β thalassemia and potential therapeutic targets.Target-based drug discovery for [Formula: see text]-globin disorders: drug target prediction using quantitative modeling with hybrid functional Petri nets.Xmn1-158 γGVariant in B-Thalassemia Intermediate Patients in South-East of Iran.Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies.Recent advances in β-thalassemias

P2860

Q26751061-62B18A95-A4AA-4E6D-A50A-8831E88AB910 Q26799214-17B328CD-E26A-4D53-B5D8-85464735BA3C Q26822810-9A901345-A833-49F5-BA1E-3F40B4D023BF Q28651652-8A315AD5-3B20-4D1A-8081-B58DF74D988D Q33361527-BA7106FC-108D-4FE0-92E2-E9B149883AD2 Q33987100-BE03AD2B-ECF4-4123-806E-06721CCBEB88 Q34322542-7E58C3F3-626D-47DF-A8C5-21F1CA60E3AA Q34890572-478C3714-A892-468E-B69A-C59DC915680B Q34973945-B66AE6CF-B177-4D11-865B-9F16E008D8C3 Q35001653-989CEA58-456A-43D5-A7E4-3813E80B89A7 Q35236041-2D4448E4-5258-4974-8799-1C19015F91FB Q35528718-53BC5592-0591-45D5-9E28-7715A08D80C0 Q35576807-6D6C0C9D-968A-4FD7-8458-C3485F9D1BC5 Q35827878-231D1A93-4E13-4031-AAED-5DBBD310C34A Q35836891-207C3429-1BC8-4519-9786-52B8DD7DB23E Q36094672-A6AB7A18-9D16-4F6B-886B-2B1B6170B0D0 Q36488272-4684477D-AB79-4D36-AE15-5E400F720C98 Q36526536-6D8F9705-21B0-49CB-B252-C9C2292D7A90 Q36554628-3C198AAA-C3F8-4E1F-B953-94433ECE547F Q36758500-C81367A7-900A-453C-A6BC-91D185E49CBC Q36803829-E648FFBF-1BAC-4EEA-9C36-659C6CB3D599 Q36831545-2C340DA8-E013-44BD-94E2-8D629E00CB53 Q36892558-9CF7D218-FA95-4497-A582-A6EC6E53C474 Q36909390-5EB69A10-D098-4F60-A045-F58CB1B20D7D Q37088889-FDD02A60-F02B-45E8-9505-D440A519C2CE Q37429238-9419D48E-B531-4BDA-8EFE-FA253A2B4940 Q37680651-0E5C9155-02F5-4CE1-8703-E0F83CBF6893 Q37702418-79767A41-BDBB-46AF-B50F-8119A8737064 Q37805602-C61ACCA3-9B9F-4672-A92D-474CCFBC069C Q37830724-930D73EE-CC67-41F1-A646-AD74681FB276 Q38088060-23443553-5E57-45DE-9924-4F6413D0722C Q38167823-758AEAA1-A520-46BF-B221-F8772FB5DE31 Q38243173-C2A52DC5-094C-48D5-83D8-2C92044532E2 Q38995849-B7FC587C-54B0-4C8D-9A9F-D7FF075AD3A9 Q39081873-8399873E-9D20-4EBD-AF3D-51085B0C7BFA Q39399184-8E8F8C44-B0C8-444C-B87B-E9D5C430BE44 Q39588171-B4EE7633-E476-4EEE-A49F-9CF8FEADDB33 Q41553568-4B5C005D-1FBD-48EB-AA5C-4A99059473E6 Q41688378-0B58C88C-9F69-43EB-84F9-3AE524D08AB0 Q41973193-7996A452-896D-4CCD-BFC0-75BB562149EE

P2860

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

http://www.wikidata.org/entity/Q34079112

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@ast

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@en

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@en-gb

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@nl

type

label

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@ast

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@en

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@en-gb

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@nl

prefLabel

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@ast

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@en

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@en-gb

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@nl

P1433

Q34079112-D830FF86-AB34-4129-8E30-BA749401E17F

P1476

Q34079112-7BEEC755-0198-4194-B07C-32ED4B7B3544

P2093

Q34079112-0027FB78-8AD6-4425-8D9E-F20B65FC04C8

Q34079112-3285BC43-EE78-4803-90CD-5A20D8F8C794

Q34079112-90BD6ABA-0867-4CE3-83EF-E14A75D6990C

Q34079112-986FA2B0-46B6-4F36-AB6C-4829CB84E315

Q34079112-ADE49B02-69F6-4D1E-99BD-336347D84381

Q34079112-B91D588A-E9DD-42D1-ACD8-52BEF06C5F0C

Q34079112-BC1D1EC7-8869-4EE7-8E11-27F9D3CA2843

Q34079112-F077FEA3-2327-4121-9111-C31FF4B8A7E4

P2860

Q34079112-5A4627F3-6C7E-482C-8803-8F0340702411

Q34079112-67FEFD47-87AC-467D-A181-0159B073F15B

Q34079112-7B37D7B6-E73C-4741-9FF5-C49C8EE69CA0

Q34079112-7F9A7142-61F4-4089-A83F-B9DBD789053C

Q34079112-92F6823D-47AA-42C9-80AA-EEBD8FE69775

Q34079112-9C59FCA8-3977-4278-9B42-F2CE7176376B

Q34079112-AC4564E8-6FBF-4A16-943B-D6EC5AECF100

Q34079112-B26A49F9-3777-43E9-9A26-BD9378B80790

Q34079112-B4CB1D35-CFB6-4147-9E84-D92BB341DA92

Q34079112-E5EE60DC-CADB-4FA8-99FF-5E7662829A7A

P304

Q34079112-0ECF73B8-8523-4B0E-AA9A-0ADE04496900

P31

Q34079112-E543E610-0DDB-4D39-A9DE-0E1480747142

P356

Q34079112-DC3470F0-7B03-4152-B740-0321EF52A9F1

P407

Q34079112-7DFC5989-9A75-4BB7-9EEB-B63EBD8A7100

P433

Q34079112-36B7CD48-99C3-4117-BE4F-CC966FAB0713

P478

Q34079112-7CEC85E9-4BC6-40C7-A69B-8ED0548E90C9

P50

Q34079112-320472F6-E552-4174-AF93-B5AD1C2A83EF

Q34079112-974F1DA9-1749-4135-8DB3-FABC45292376

Q34079112-A45A2FF9-D009-4CD8-8F16-63B9235C89F3

P577

Q34079112-F1778987-7D66-4B29-98DE-51ED9F80BDD4

P5875

Q34079112-9A80DEB4-D117-46CD-A6A5-F1E762775E44

P698

Q34079112-D12C6CF4-0B9C-4D01-9D42-A60780FE9477

P932

Q34079112-93F55F84-BC9D-437B-945B-330C886DEF5D

P356

BLOOD-2009-04-217901

P1433

P1476

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

@en

P2093

Antonio Cao

http://www.w3.org/2001/XMLSchema#string

Gianluca Usala

http://www.w3.org/2001/XMLSchema#string

Lucia Perseu

http://www.w3.org/2001/XMLSchema#string

Maria Carla Sollaino

http://www.w3.org/2001/XMLSchema#string

Maria Eliana Lai

http://www.w3.org/2001/XMLSchema#string

Renzo Galanello

http://www.w3.org/2001/XMLSchema#string

Stefania Satta

http://www.w3.org/2001/XMLSchema#string

Susanna Barella

http://www.w3.org/2001/XMLSchema#string

P2860

BCL11A represses HBG transcription in K562 cells

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.

Genetic modifiers of beta-thalassemia.

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Genotype-phenotype correlations in beta-thalassemias.

Modulation of the phenotypic diversity of sickle cell anemia.

Molecular analysis of beta zero-thalassemia intermedia in Sardinia.

P304

3935-3937

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2009-04-217901

http://www.w3.org/2001/XMLSchema#string

P407

P433

18

http://www.w3.org/2001/XMLSchema#string

P478

114

http://www.w3.org/2001/XMLSchema#string

P50

Gonçalo Abecasis

P577

2009-08-20T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26756673

http://www.w3.org/2001/XMLSchema#string

P698

19696200

http://www.w3.org/2001/XMLSchema#string

P932

2925722

http://www.w3.org/2001/XMLSchema#string