PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs
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Transmission of influenza A virusesOne health, multiple challenges: The inter-species transmission of influenza A virusAnalysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmissionIsolation and genetic characterization of H5N2 influenza viruses from pigs in Korea.Adaptive strategies of the influenza virus polymerase for replication in humansMultiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human CellsSubstitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in micePandemic Seasonal H1N1 Reassortants Recovered from Patient Material Display a Phenotype Similar to That of the Seasonal Parent.Pandemic (H1N1) 2009 virus revisited: an evolutionary retrospectiveGenetic evolution of low pathogenecity H9N2 avian influenza viruses in Tunisia: acquisition of new mutations.Polymerase activity of hybrid ribonucleoprotein complexes generated from reassortment between 2009 pandemic H1N1 and seasonal H3N2 influenza A viruses.Phylogenetic diversity and genotypic complexity of H1N1 subtype swine influenza viruses isolated in mainland ChinaPotency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strainAdaptation of avian influenza A virus polymerase in mammals to overcome the host species barrierNovel genotypes of H9N2 influenza A viruses isolated from poultry in Pakistan containing NS genes similar to highly pathogenic H7N3 and H5N1 viruses.Comparative pathogenesis of an avian H5N2 and a swine H1N1 influenza virus in pigs.High interferon type I responses in the lung, plasma and spleen during highly pathogenic H5N1 infection of chicken.Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.MDA5 can be exploited as efficacious genetic adjuvant for DNA vaccination against lethal H5N1 influenza virus infection in chickens.Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig modelsVaccination with recombinant RNA replicon particles protects chickens from H5N1 highly pathogenic avian influenza virus.Biological and protective properties of immune sera directed to the influenza virus neuraminidase.Additional Evidence That the Polymerase Subunits Contribute to the Viral Replication and the Virulence of H5N1 Avian Influenza Virus Isolates in Mice.Investigation of influenza virus polymerase activity in pig cells.Different incubation temperatures affect viral polymerase activity and yields of low-pathogenic avian influenza viruses in embryonated chicken eggs.Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes.The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model.Hemagglutinin-dependent tropism of H5N1 avian influenza virus for human endothelial cells.The avian and mammalian host range of highly pathogenic avian H5N1 influenza.Isolation and characterization of H9N2 influenza virus isolates from poultry respiratory disease outbreak.Genetic characterization of highly pathogenic avian influenza H5N1 viruses isolated from naturally infected pigeons in Egypt.Highly pathogenic avian influenza virus H5N1 controls type I IFN induction in chicken macrophage HD-11 cells: a polygenic trait that involves NS1 and the polymerase complex.Variability of tropism and replicative capacity of two naturally occurring influenza A H9N2 viruses in cell cultures from different tissues.Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.Unlocking pandemic potential: prevalence and spatial patterns of key substitutions in avian influenza H5N1 in Egyptian isolates.
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PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
PB2 protein of a highly pathog ...... replication potential in pigs
@en
PB2 protein of a highly pathog ...... ain A/chicken/Yamaguchi/7/2004
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type
label
PB2 protein of a highly pathog ...... replication potential in pigs
@en
PB2 protein of a highly pathog ...... ain A/chicken/Yamaguchi/7/2004
@nl
prefLabel
PB2 protein of a highly pathog ...... replication potential in pigs
@en
PB2 protein of a highly pathog ...... ain A/chicken/Yamaguchi/7/2004
@nl
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P356
P1433
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PB2 protein of a highly pathog ...... replication potential in pigs
@en
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Hiroichi Ozaki
Hiroshi Kida
Masatoshi Okamatsu
Naoki Nomura
Rashid Manzoor
Yoshihiro Sakoda
Yoshimi Tsuda
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P304
P356
10.1128/JVI.01879-08
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P577
2008-12-03T00:00:00Z