Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.
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Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer developmentProgesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexesMolecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification.Heregulin Co-opts PR Transcriptional Action Via Stat3 Role As a Coregulator to Drive Cancer Growth.Minireview: Tipping the balance: ligand-independent activation of steroid receptors.Hypothesized role of pregnancy hormones on HER2+ breast tumor development.Role of phosphorylation in progesterone receptor signaling and specificitySmall interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer modelClinical relevance of ErbB-2/HER2 nuclear expression in breast cancer.Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growthMolecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast CancerLoss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesisER and PR signaling nodes during mammary gland development.Steroid receptor phosphorylation: Assigning function to site-specific phosphorylation.Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy.Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis.Activation of Stat3 in renal tumors.Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer.Phosphorylation of STAT3 correlates with HER2 status, but not with survival in pancreatic ductal adenocarcinoma.Progesterone receptor (PR) variants exist in breast cancer cells characterised as PR negative.Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance.Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms
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P2860
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Activation of Stat3 by heregul ...... g drives breast cancer growth.
@en
Activation of Stat3 by heregul ...... g drives breast cancer growth.
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Activation of Stat3 by heregul ...... g drives breast cancer growth.
@en
Activation of Stat3 by heregul ...... g drives breast cancer growth.
@nl
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Activation of Stat3 by heregul ...... g drives breast cancer growth.
@en
Activation of Stat3 by heregul ...... g drives breast cancer growth.
@nl
P2093
P2860
P356
P1476
Activation of Stat3 by heregul ...... g drives breast cancer growth.
@en
P2093
Cecilia J Proietti
Cinthia Rosemblit
Eduardo H Charreau
Martín A Rivas
María Celeste Díaz Flaqué
Patricia V Elizalde
Roxana Schillaci
Wendy Beguelin
P2860
P304
P356
10.1128/MCB.00853-08
P407
P577
2008-12-22T00:00:00Z