E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors
about
Factors and networks that underpin early hematopoiesisThe establishment of B versus T cell identityLy6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell developmentAdult hematopoietic stem cells require NKAP for maintenance and survivalCyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.A tamoxifen inducible knock-in allele for investigation of E2A function.From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitmentA global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cellsIdentification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid developmentHow B cells influence bone biology in health and diseaseB lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1.E proteins and the regulation of early lymphocyte developmentRequirement for ssbp2 in hematopoietic stem cell maintenance and stress responsePrognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient mice.E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.Chronic exposure to a TLR ligand injures hematopoietic stem cells.Mtg16/Eto2 contributes to murine T-cell development.Role of helix-loop-helix proteins during differentiation of erythroid cells.Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.Nfix expression critically modulates early B lymphopoiesis and myelopoiesisMyocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.Myeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence.Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47.The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors.Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.The non-canonical Wnt pathway negatively regulates dendritic cell differentiation by inhibiting the expansion of Flt3(+) lymphocyte-primed multipotent precursors.Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.E2A predicts prognosis of colorectal cancer patients and regulates cancer cell growth by targeting miR-320aID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signalingMechanism governing a stem cell-generating cis-regulatory element.T-cell lineage determination.Molecular resolution of the B cell landscape.
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P2860
E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
E2A proteins maintain the hema ...... and myeloerythroid progenitors
@en
E2A proteins maintain the hema ...... nd myeloerythroid progenitors.
@nl
type
label
E2A proteins maintain the hema ...... and myeloerythroid progenitors
@en
E2A proteins maintain the hema ...... nd myeloerythroid progenitors.
@nl
prefLabel
E2A proteins maintain the hema ...... and myeloerythroid progenitors
@en
E2A proteins maintain the hema ...... nd myeloerythroid progenitors.
@nl
P2093
P2860
P356
P1476
E2A proteins maintain the hema ...... and myeloerythroid progenitors
@en
P2093
Cornelis Murre
Craig L Semerad
Elinore M Mercer
Irving L Weissman
Matthew A Inlay
P2860
P304
P356
10.1073/PNAS.0808866106
P407
P577
2009-01-30T00:00:00Z