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Automated drug screening with contractile muscle tissue engineered from dystrophic myoblastsDystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery.High-content drug screening with engineered musculoskeletal tissuesDystrophin isoform induction in vivo by antisense-mediated alternative splicing.The different impact of a high fat diet on dystrophic mdx and control C57Bl/10 micePharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trialsAn omega-3 fatty acid-enriched diet prevents skeletal muscle lesions in a hamster model of dystrophy.IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse.Hmgb3 is regulated by microRNA-206 during muscle regeneration.Electrical stimuli are anti-apoptotic in skeletal muscle via extracellular ATP. Alteration of this signal in Mdx mice is a likely cause of dystrophy.NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy.Enhancing translation: guidelines for standard pre-clinical experiments in mdx miceIncreased taurine in pre-weaned juvenile mdx mice greatly reduces the acute onset of myofibre necrosis and dystropathology and prevents inflammation.A necrotic stimulus is required to maximize matrix-mediated myogenesis in miceLevels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy.Cell based therapy for Duchenne muscular dystrophy.Comparison of Experimental Protocols of Physical Exercise for mdx Mice and Duchenne Muscular Dystrophy Patients.Concise review: stem cell therapy for muscular dystrophies.Increasing taurine intake and taurine synthesis improves skeletal muscle function in the mdx mouse model for Duchenne muscular dystrophy.Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice.Beneficial effects of high dose taurine treatment in juvenile dystrophic mdx mice are offset by growth restriction.Pre-clinical evaluation of N-acetylcysteine reveals side effects in the mdx mouse model of Duchenne muscular dystrophy.Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Two-tiered hypotheses for Duchenne muscular dystrophy.
@en
Two-tiered hypotheses for Duchenne muscular dystrophy.
@nl
type
label
Two-tiered hypotheses for Duchenne muscular dystrophy.
@en
Two-tiered hypotheses for Duchenne muscular dystrophy.
@nl
prefLabel
Two-tiered hypotheses for Duchenne muscular dystrophy.
@en
Two-tiered hypotheses for Duchenne muscular dystrophy.
@nl
P1476
Two-tiered hypotheses for Duchenne muscular dystrophy
@en
P2093
M D Grounds
P2888
P304
P356
10.1007/S00018-008-7574-8
P577
2008-06-01T00:00:00Z