Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.
about
P450cam Visits an Open Conformation in the Absence of Substrate ,The structure of CYP101D2 unveils a potential path for substrate entry into the active siteThe crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding siteHuman cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.The Mycobacterium tuberculosis cytochrome P450 system.Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substatesEnhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acidDynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopyReengineering rate-limiting, millisecond enzyme motions by introduction of an unnatural amino acid.Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography.Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques.The dynamics of camphor in the cytochrome P450 CYP101D2.Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.Playing with the molecules of life.Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119
P2860
Q27660275-B64EE635-8925-41CA-84DA-DAEBF9F80024Q27665073-D6D35C82-81CB-4165-BB26-99ECEA7B4615Q27681160-2EE7CB54-6E83-4BB1-9E0F-6573C5391E32Q30360659-9051BE74-6B84-4BB3-A740-F5BE078D31BAQ30396630-C9BFA51F-B13B-4721-B28A-EB4C24914A91Q33615471-22F60F2F-6520-4E5A-81D2-EB961B296867Q33744590-E9554280-19D8-46ED-BCFE-0EEE0397AFE7Q33762335-7539E4F2-4FF0-48AA-B7D4-A780FA89D69AQ34765392-E2D174BF-95A7-4656-97B4-DBF904A42D16Q35069990-8A62FF3C-8161-4104-895F-4650CDEABE63Q35106787-CDCF1C61-80B6-4659-BB9E-57C95996A627Q35450924-391FE5ED-132B-4317-8F27-2C0E94309D0EQ41333940-1495D0AA-FC0D-4360-963A-06DBBC9C4D6DQ41865917-8E7F7670-6385-4A68-AF48-2B0CE486D144Q42731458-F244D1BC-AA9E-4CC0-9B61-75A1BD4D3BFCQ49968034-F23F7825-60B3-4071-BC52-2EDB5D6AC719Q57295926-3CFD0CD7-F9D8-4F34-85F3-E7C165E1D584
P2860
Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Ligand-induced conformational ...... (13)C-p-methoxyphenylalanine.
@en
Ligand-induced conformational ...... with the unnatural amino acid
@nl
type
label
Ligand-induced conformational ...... (13)C-p-methoxyphenylalanine.
@en
Ligand-induced conformational ...... with the unnatural amino acid
@nl
prefLabel
Ligand-induced conformational ...... (13)C-p-methoxyphenylalanine.
@en
Ligand-induced conformational ...... with the unnatural amino acid
@nl
P2093
P2860
P50
P356
P1476
Ligand-induced conformational ...... d (13)C-p-methoxyphenylalanine
@en
P2093
Clinton R Nishida
John D Gross
Paul R Ortiz de Montellano
Yongying Jiang
P2860
P304
16168-16169
P356
10.1021/JA8071463
P407
P577
2008-12-01T00:00:00Z