Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
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Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selectionInteractions between CYP3A4 and Dietary PolyphenolsUnderstanding the mechanism of cytochrome P450 3A4: recent advances and remaining problemsCooperativity in monomeric enzymes with single ligand-binding sitesUse of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substratesIdentifying cytochrome p450 functional networks and their allosteric regulatory elementsA numerical method for analysis of in vitro time-dependent inhibition data. Part 1. Theoretical considerationsUse of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9.Inhibition of recombinant cytochrome P450 isoforms 2D6 and 2C9 by diverse drug-like moleculesExplaining the atypical reaction profiles of heme enzymes with a novel mechanistic hypothesis and kinetic treatmentExperimental approaches to evaluate activities of cytochromes P450 3AAnalysis of heterotropic cooperativity in cytochrome P450 3A4 using alpha-naphthoflavone and testosterone.Structural basis for ligand promiscuity in cytochrome P450 3A4.Allosteric activation of cytochrome P450 3A4 by α-naphthoflavone: branch point regulation revealed by isotope dilution analysisA key cytochrome P450 hydroxylase in pradimicin biosynthesis.A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.Kinetics of regulatory serine variants of tyrosine hydroxylase with cyclic AMP-dependent protein kinase and extracellular signal-regulated protein kinase 2.Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand InteractionsElectrochemical detection of anti-breast-cancer agents in human serum by cytochrome P450-coated carbon nanotubes.In Silico Predictions of Drug - Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance.Indole peroxygenase activity of indoleamine 2,3-dioxygenaseCurrent views on the fundamental mechanisms of cytochrome P450 allosterism.Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets.Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation.Understanding cooperativity in human p450 mediated drug-drug interactions.Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine.Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancerCooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone.A comparison of substrate dynamics in human CYP2E1 and CYP2A6Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.Cooperative properties of cytochromes P450.Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome.Substrate inhibition kinetics in drug metabolism reactions.Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling.Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4
P2860
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P2860
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
@ast
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
@en
type
label
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
@ast
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
@en
prefLabel
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
@ast
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
@en
P1476
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions.
@en
P2093
William M Atkins
P304
P356
10.1146/ANNUREV.PHARMTOX.45.120403.100004
P577
2005-01-01T00:00:00Z