CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression - Wikidata - wikimedia - TriplyDB

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

http://www.wikidata.org/entity/Q37106255

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COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase Dynamic regulation of the COP9 signalosome in response to DNA damage CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response.An atlas of altered expression of deubiquitinating enzymes in human cancer JAB1/CSN5: a new player in cell cycle control and cancer Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5.Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy.Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR.CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradation Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer.Roles of COP9 signalosome in cancer.Spotlight on the role of COP1 in tumorigenesis.The emerging roles of Jab1/CSN5 in cancer.Roles of Multifunctional COP9 Signalosome Complex in Cell Fate and Implications for Drug Discovery.CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1 Jab1 is a target of EGFR signaling in ERalpha-negative breast cancer.Role of CSN5/JAB1 in Wnt/β-catenin activation in colorectal cancer cells.Structural biology: Corralling a protein-degradation regulator.Analysis of differential gene expression profile identifies novel biomarkers for breast cancer.Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells.Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer.COP9 signalosome subunit CSN5, but not CSN6, is upregulated in lung adenocarcinoma and predicts poor prognosis.COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL.A Targeted RNAi Screen Reveals Drosophila Female-Sterile Genes That Control the Size of Germline Stem Cell Niche During Development.The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver

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CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

http://www.wikidata.org/entity/Q37106255

description

2008年论文

@zh

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scienca artikolo

@eo

scientific article published on 1 January 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

name

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

@en

CSN5 isopeptidase activity lin ...... to breast cancer progression.

@nl

type

label

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

@en

CSN5 isopeptidase activity lin ...... to breast cancer progression.

@nl

prefLabel

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

@en

CSN5 isopeptidase activity lin ...... to breast cancer progression.

@nl

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0008-5472.CAN-07-3060

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Cancer Research

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CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

@en

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Adam S Adler

http://www.w3.org/2001/XMLSchema#string

David J Wong

http://www.w3.org/2001/XMLSchema#string

Howard Y Chang

http://www.w3.org/2001/XMLSchema#string

Laurie E Littlepage

http://www.w3.org/2001/XMLSchema#string

Meihong Lin

http://www.w3.org/2001/XMLSchema#string

Tiara L A Kawahara

http://www.w3.org/2001/XMLSchema#string

Zena Werb

http://www.w3.org/2001/XMLSchema#string

P2860

JAMM: a metalloprotease-like zinc site in the proteasome and signalosome

Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds

CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha

Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation

Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels.

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

Creation of human tumour cells with defined genetic elements

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506-515

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10.1158/0008-5472.CAN-07-3060

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2

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68

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2008-01-01T00:00:00Z

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5651076

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18199546

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2646416

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