CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
about
COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phaseDynamic regulation of the COP9 signalosome in response to DNA damageCSNAP Is a Stoichiometric Subunit of the COP9 SignalosomeTargeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agentMolecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response.An atlas of altered expression of deubiquitinating enzymes in human cancerJAB1/CSN5: a new player in cell cycle control and cancerStat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5.Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy.Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR.CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradationEmerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer.Roles of COP9 signalosome in cancer.Spotlight on the role of COP1 in tumorigenesis.The emerging roles of Jab1/CSN5 in cancer.Roles of Multifunctional COP9 Signalosome Complex in Cell Fate and Implications for Drug Discovery.CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1Jab1 is a target of EGFR signaling in ERalpha-negative breast cancer.Role of CSN5/JAB1 in Wnt/β-catenin activation in colorectal cancer cells.Structural biology: Corralling a protein-degradation regulator.Analysis of differential gene expression profile identifies novel biomarkers for breast cancer.Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells.Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer.COP9 signalosome subunit CSN5, but not CSN6, is upregulated in lung adenocarcinoma and predicts poor prognosis.COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL.A Targeted RNAi Screen Reveals Drosophila Female-Sterile Genes That Control the Size of Germline Stem Cell Niche During Development.The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver
P2860
Q24293399-6389E760-E968-44F6-9D36-5FDE8C422406Q24319983-3173F055-4778-4B15-BDCD-897E0DF9D9E3Q28115049-1C6EEA88-1306-45B9-905D-C445C87CCD89Q28484382-870DBE44-B9F8-4984-A07F-241C12E78710Q30502702-A8E29175-A581-4033-A99B-147A07612C70Q33808690-41B15666-4609-4B52-A7B3-54639181732BQ34292695-1A0038ED-D20F-4787-8CEC-C5EFC5810312Q35558119-473174CA-EF0E-42B5-9EF2-36C9EAA08847Q35974190-8750AC94-CF99-492E-B181-B854F70CA7CCQ36163496-64540817-5587-4713-9DB1-8EFED3A77455Q36216079-70BA8264-D85D-4E35-AC86-5F74A59F6242Q37063329-D2A66356-5111-454E-AAD3-679CC32C6508Q37189468-9537B787-5070-49E6-A4F0-42A043CD99FEQ37683027-30AC4AF1-62F6-45E7-A8D5-45A84EBE27DFQ37923711-D0835663-0D38-48BF-98E9-7DA820F7C665Q38016673-5A60EB50-355F-473A-BBEE-DD81AD27135FQ38842175-BE001ECB-91CB-4B87-BFEF-7118D9FD1E48Q39015104-40FEEB15-FBEA-49AB-BED2-332393576474Q39538233-721C3B10-F81A-47E4-A629-72ABE343D5B4Q39974866-1FCAD448-DB60-41A0-B816-AF4951902D33Q43424639-551FA347-D518-4389-9522-80E2F231FC97Q46613519-F37A6833-51CA-4E58-95A5-90FD05F945F5Q49188421-DC2BAAAB-64F1-45E5-9012-8B483D38F2F0Q52649730-222C43FE-0373-4FB8-B0D6-5DDC5573ED16Q52657204-610095D4-70B4-48A3-A027-C746CE43BB55Q52715760-CF09CD74-1BE6-42B1-91D2-331F678BDCCEQ55180650-93FFE191-5762-4B45-99ED-EA01070DC249Q55421968-287F6031-37E9-48DB-A983-0F02B6BD52B9Q58882257-F66280C5-2214-4FFC-BB38-B61CF96E250D
P2860
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
description
2008年论文
@zh
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scienca artikolo
@eo
scientific article published on 1 January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
name
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
@en
CSN5 isopeptidase activity lin ...... to breast cancer progression.
@nl
type
label
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
@en
CSN5 isopeptidase activity lin ...... to breast cancer progression.
@nl
prefLabel
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
@en
CSN5 isopeptidase activity lin ...... to breast cancer progression.
@nl
P2093
P2860
P1433
P1476
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression
@en
P2093
Adam S Adler
David J Wong
Howard Y Chang
Laurie E Littlepage
Meihong Lin
Tiara L A Kawahara
P2860
P304
P356
10.1158/0008-5472.CAN-07-3060
P407
P50
P577
2008-01-01T00:00:00Z