The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion
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Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for AllotransplantationThe role of naive T cell precursor frequency and recruitment in dictating immune response magnitudeTGF-β sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responsesEcological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populationsAnalysis of the T Cell Response to Zika Virus and Identification of a Novel CD8+ T Cell Epitope in Immunocompetent MiceNonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulumGeneration and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant MiceImmune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes.Cutting edge: innate memory CD8+ T cells are distinct from homeostatic expanded CD8+ T cells and rapidly respond to primary antigenic stimuli.Memory CD8+ T cell differentiationITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner.Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansionEvolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire.Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cellsImmune memory and aging: an infinite or finite resource?Interleukin-17 promotes early allograft inflammation.Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.Alternative memory in the CD8 T cell lineageThe narrowing of the CD8 T cell repertoire in old ageConvergent recombination shapes the clonotypic landscape of the naive T-cell repertoire.Early signals during CD8 T cell priming regulate the generation of central memory cells.Transient lymphopenia breaks costimulatory blockade-based peripheral tolerance and initiates cardiac allograft rejectionIL-2 complex treatment can protect naive mice from bacterial and viral infection.Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them.The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunityAcute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses.Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions.Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokinesType I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells.Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression.Naive T cell maintenance and function in human aging.Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo.Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes.Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination.Derivation and maintenance of virtual memory CD8 T cells.Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursorsAnalysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4(+) and CD8(+) memory formation.Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses.
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The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 02 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The antigen-specific CD8+ T ce ...... rkers of homeostatic expansion
@en
The antigen-specific CD8+ T ce ...... kers of homeostatic expansion.
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type
label
The antigen-specific CD8+ T ce ...... rkers of homeostatic expansion
@en
The antigen-specific CD8+ T ce ...... kers of homeostatic expansion.
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prefLabel
The antigen-specific CD8+ T ce ...... rkers of homeostatic expansion
@en
The antigen-specific CD8+ T ce ...... kers of homeostatic expansion.
@nl
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P2860
P356
P1476
The antigen-specific CD8+ T ce ...... rkers of homeostatic expansion
@en
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Adovi D Akue
Catherine Haluszczak
Lenka Teodorovic
Lisa D S Johnson
Ross M Kedl
Sara E Hamilton
Stephen C Jameson
P2860
P304
P356
10.1084/JEM.20081829
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P577
2009-02-02T00:00:00Z