Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors
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Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans.Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells.The longevity of memory CD8 T cell responses after repetitive antigen stimulationsAging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.Understanding immunosenescence to improve responses to vaccinesCooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity.Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.The combined molecular adjuvant CASAC enhances the CD8+ T cell response to a tumor-associated self-antigen in aged, immunosenescent mice.Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.Targets of immune regeneration in rheumatoid arthritis.Age-related changes in CD8 T cell homeostasis and immunity to infectionInfection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice.Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.Use it or lose it: establishment and persistence of T cell memory.Reduced naïve CD8(+) T-cell priming efficacy in elderly adults.Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice.Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesisCharacterization of age-associated exhausted CD8⁺ T cells defined by increased expression of Tim-3 and PD-1.Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults.Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses.The promised land of human immunologyDose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza.Influenza virus specific CD8⁺ T cells exacerbate infection following high dose influenza challenge of aged mice.Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalities.Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging.Age-related changes in the gene expression profile of antigen-specific mouse CD8+ T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination.Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects.Antiviral memory phenotype T cells in unexposed adults.Sizing up the key determinants of the CD8(+) T cell response.Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs.Antigen-specific naive CD8+ T cells produce a single pulse of IFN-γ in vivo within hours of infection, but without antiviral effect.Immune tolerance in liver disease.The twilight of immunity: emerging concepts in aging of the immune system.T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence.The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns.A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection
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P2860
Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Defective CD8 T cell responses ...... s in virus-specific precursors
@ast
Defective CD8 T cell responses ...... s in virus-specific precursors
@en
type
label
Defective CD8 T cell responses ...... s in virus-specific precursors
@ast
Defective CD8 T cell responses ...... s in virus-specific precursors
@en
prefLabel
Defective CD8 T cell responses ...... s in virus-specific precursors
@ast
Defective CD8 T cell responses ...... s in virus-specific precursors
@en
P2093
P2860
P356
P1476
Defective CD8 T cell responses ...... s in virus-specific precursors
@en
P2093
Brian J Laidlaw
Daniel R Goldstein
E John Wherry
Hildegund C J Ertl
Travis A Doering
Vilma Decman
P2860
P304
P356
10.4049/JIMMUNOL.1101098
P407
P577
2012-01-13T00:00:00Z