Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. - Wikidata - wikimedia - TriplyDB

Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.

Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.

http://www.wikidata.org/entity/Q37112089

about

Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development Phospholipase A2 superfamily members play divergent roles after spinal cord injury.Membrane and inhibitor interactions of intracellular phospholipases A2.Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis.2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides Phospholipase A2 structure/function, mechanism, and signaling.Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease.New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2.Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.Emerging roles of lipid metabolism in cancer metastasis.Phospholipase A2 inhibitors for the treatment of inflammatory diseases: a patent review (2010--present).Chemical modulation of glycerolipid signaling and metabolic pathways.Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2.2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2.2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors.Trifluoromethyl ketones: properties, preparation, and application.Catalytic Enantioselective Conjugate Alkynylation of α,β-Unsaturated 1,1,1-Trifluoromethyl Ketones with Terminal Alkynes.Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb.

P2860

Q26997377-52292C38-177A-483B-9E83-FB28CFC6E1DC Q30785490-C4BE412D-2C6A-4497-AC0D-10630B20DC9E Q33833653-42187EAD-1864-4A50-A221-9713019E9388 Q35070149-E2943EF5-2E20-449B-BE82-DC0EF3D060E2 Q35609640-87550B4C-71C4-46CA-88AD-BEDE8FF9369A Q36945608-C92521D5-C695-499B-A02B-808AB2C5754A Q37181286-8781C9CC-D9EA-451C-8D0B-04ED8219DB57 Q37226101-59F4F95B-722A-4451-A1B4-D1740C5252D0 Q37326136-C9C3D967-7DDB-4079-90FD-5844CE7379EE Q37421407-CF841DA1-AF3F-400D-BDAB-F53E24865B62 Q37443756-0296AE0F-7CD9-4C0D-859C-EDBABBDE51AC Q37658843-64CA05F1-F21A-48D9-8B58-65C7EE84FDD0 Q37747513-166B8114-5533-4A24-A2E5-BB27CEF4B9BC Q38072094-DF39557D-671B-4C9E-8451-4CB56F688992 Q38179801-D03FAC8B-4BE1-4DC5-9195-F312BEF590E6 Q39671868-BDCCBD5D-5816-44B2-96BC-13BD71FFC823 Q41204206-79F2E16C-64A6-493F-9F20-AF41BD54BF7A Q41634441-9FD88FBF-D586-493D-A683-96AD37F879AB Q43747404-D5F67C7F-B3EA-426A-B9F1-7347BFB983F6 Q45111408-B8DE724E-3F5B-464A-BC78-22F64C9039D1 Q48189903-84BDC141-14CD-4BBF-8D5F-3F7A4099E37B Q52890440-47ECAC96-6BC0-4585-8619-46A94A44339A

P2860

Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.

http://www.wikidata.org/entity/Q37112089

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on December 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Synthesis of polyfluoro ketone ...... uman phospholipase A2 enzymes.

@en

Synthesis of polyfluoro ketone ...... uman phospholipase A2 enzymes.

@nl

type

label

Synthesis of polyfluoro ketone ...... uman phospholipase A2 enzymes.

@en

Synthesis of polyfluoro ketone ...... uman phospholipase A2 enzymes.

@nl

prefLabel

Synthesis of polyfluoro ketone ...... uman phospholipase A2 enzymes.

@en

Synthesis of polyfluoro ketone ...... uman phospholipase A2 enzymes.

@nl

P1433

Q37112089-C3276C9C-DC62-49D9-866C-CA4A4AC60E78

P1476

Q37112089-13055130-8695-40C4-B6DF-C3E8CC41A360

P2093

Q37112089-46AB66E4-B24F-4991-AB8B-F35F96BDEE23

Q37112089-8BD6327E-19F0-481B-BF66-E12C6A3BCEBB

Q37112089-8E15FE4D-5461-467E-9F7D-7943B39FCA5F

Q37112089-A86B919D-A275-43B7-8AFF-03D3F0F09514

Q37112089-D3AAE213-BC2E-48F9-A079-BA639473F431

P2860

Q37112089-038DBDFA-08C0-43F8-98CB-7C71078C1EF0

Q37112089-045209F2-FFA5-4E2A-8FD9-4CD77CD4077B

Q37112089-06790FEA-C523-423B-983B-727D4844AC08

Q37112089-0966F7BE-098D-459C-87D4-24A0499261FF

Q37112089-0F69B612-0D74-48BD-A1D0-BF2B7CD110BB

Q37112089-10BBA6FB-1448-419B-825B-4A0D5B4C697F

Q37112089-10F7AA03-F554-4C4C-B5C2-78CA917F9951

Q37112089-1C83B8B0-FFD8-492D-8669-4FE569A11DC0

Q37112089-1CA324CC-C797-47EB-AAFF-0BAEE522A4BC

Q37112089-1DE65B77-6DC6-426D-BC35-33238E81E970

P304

Q37112089-2022208C-C004-4D0F-9641-CA15DCE02D11

P31

Q37112089-A1330227-52D4-40B8-AF49-89800F73832E

P356

Q37112089-E49D6ED7-89A3-486E-8AFB-C4451F54FCA7

P407

Q37112089-8D8E0C1D-3E28-4A6A-B150-186BDC01320E

P433

Q37112089-003F13A9-F2EE-4329-B80D-C8EC8537ECEA

P478

Q37112089-641B19C3-B936-4AB4-BDA3-5EC22D17AF32

P50

Q37112089-152839A9-D15E-4219-85AA-A7D249FD9CCC

Q37112089-D4CF742A-4F66-4E38-94FA-9A344AA1564A

P577

Q37112089-DEDC4EFD-100F-4CF9-88DE-8A4E95E0CAE9

P5875

Q37112089-77AFD035-8FF7-4E6E-A84A-75155EB84A13

P698

Q37112089-05AC67E8-5484-4F74-BCDD-7495AFEBB596

P932

Q37112089-5836C318-3CFB-4235-BE39-4B93BC9813A0

P356

P1433

Journal of Medicinal Chemistry

P1476

Synthesis of polyfluoro ketone ...... uman phospholipase A2 enzymes.

@en

P2093

Constantinos Baskakis

http://www.w3.org/2001/XMLSchema#string

Daren Stephens

http://www.w3.org/2001/XMLSchema#string

George Kokotos

http://www.w3.org/2001/XMLSchema#string

Naomi Cotton

http://www.w3.org/2001/XMLSchema#string

Violetta Constantinou-Kokotou

http://www.w3.org/2001/XMLSchema#string

P2860

Fluorine in pharmaceuticals: looking beyond intuition

Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha

Phospholipase A2 enzymes

Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.

Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha.

Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury.

Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption.

Calcium-independent phospholipase A(2): structure and function.

Interfacial enzymology: the secreted phospholipase A(2)-paradigm.

P304

8027-8037

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/JM800649Q

http://www.w3.org/2001/XMLSchema#string

P407

P433

24

http://www.w3.org/2001/XMLSchema#string

P478

51

http://www.w3.org/2001/XMLSchema#string

P50

Edward A. Dennis

Victoria Magrioti

P577

2008-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23568727

http://www.w3.org/2001/XMLSchema#string

P698

19053783

http://www.w3.org/2001/XMLSchema#string

P932

2649009

http://www.w3.org/2001/XMLSchema#string