DNA double-strand breaks: a potential causative factor for mammalian aging?
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Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with ageDNA Damage in Chronic Kidney Disease: Evaluation of Clinical BiomarkersSCID dogs: similar transplant potential but distinct intra-uterine growth defects and premature replicative senescence compared with SCID mice.A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage?Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.Stem cells and aging: a chicken-or-the-egg issue?Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.Aging genomes: a necessary evil in the logic of life.Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing.Metabolism, genomics, and DNA repair in the mouse aging liver.The ageing epigenome: damaged beyond repair?SPATA12 and its possible role in DNA damage induced by ultraviolet-C.Genomic damage in endstage renal disease-contribution of uremic toxinsAge and gender effects on DNA strand break repair in peripheral blood mononuclear cells.p53 and rapamycin are additive.The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damageDNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age.Promoter methylation and age-related downregulation of Klotho in rhesus monkeyGenetic damage in patients with chronic kidney disease, peritoneal dialysis and haemodialysis: a comparative study.Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase.Response of Mouse Zygotes Treated with Mild Hydrogen Peroxide as a Model to Reveal Novel Mechanisms of Oxidative Stress-Induced Injury in Early Embryos.Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues.Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repairDNA polymerases in nonhomologous end joining: are there any benefits to standing out from the crowd?p53 as an intervention target for cancer and aging.The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte.Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair.Early age decline in DNA repair capacity in the liver: in depth profile of differential gene expression.Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress.AT1 receptor antagonist candesartan attenuates genomic damage in peripheral blood lymphocytes of patients on maintenance hemodialysis treatment.LINE-1 Retrotransposons in Healthy and Diseased Human Brain.Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage.Age-related change in γH2AX of Drosophila muscle: its significance as a marker for muscle damage and longevity.Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population.
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P2860
DNA double-strand breaks: a potential causative factor for mammalian aging?
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 February 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
DNA double-strand breaks: a potential causative factor for mammalian aging?
@en
DNA double-strand breaks: a potential causative factor for mammalian aging?
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type
label
DNA double-strand breaks: a potential causative factor for mammalian aging?
@en
DNA double-strand breaks: a potential causative factor for mammalian aging?
@nl
prefLabel
DNA double-strand breaks: a potential causative factor for mammalian aging?
@en
DNA double-strand breaks: a potential causative factor for mammalian aging?
@nl
P2093
P2860
P1476
DNA double-strand breaks: a potential causative factor for mammalian aging?
@en
P2093
James R Mitchell
Paul Hasty
P2860
P304
P356
10.1016/J.MAD.2008.02.002
P577
2008-02-14T00:00:00Z