Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist

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Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides.Progress towards the development of SH2 domain inhibitors.3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.

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P2860

Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist

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http://www.wikidata.org/entity/Q37117488

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Selectivity and mechanism of a ...... gy 2 domain binding antagonist

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Selectivity and mechanism of a ...... y 2 domain binding antagonist.

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Selectivity and mechanism of a ...... gy 2 domain binding antagonist

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Selectivity and mechanism of a ...... y 2 domain binding antagonist.

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Selectivity and mechanism of a ...... gy 2 domain binding antagonist

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Selectivity and mechanism of a ...... y 2 domain binding antagonist.

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P1476

Selectivity and mechanism of a ...... gy 2 domain binding antagonist

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P2093

Benedetta Peruzzi

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Ettore Appella

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Gagani Athauda

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Karen M Worthy

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Lakshman K Bindu

http://www.w3.org/2001/XMLSchema#string

Lisa M Miller Jenkins

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Robert J Fisher

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Terrence R Burke

http://www.w3.org/2001/XMLSchema#string

Zhen-Dan Shi

http://www.w3.org/2001/XMLSchema#string

P2860

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data

SH2 domains recognize specific phosphopeptide sequences

Oncogenic kinase signalling

Nuclear localization and chromatin targets of p21-activated kinase 1

p21-activated kinases in cancer

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling.

Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy.

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7459-7468

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scholarly article

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10.1021/JM800523U

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English

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Donald P. Bottaro

Alessio Giubellino

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2008-12-01T00:00:00Z

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231563456

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18989951

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2651228

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Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist

about

P2860

P2860

Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932