Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers.
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Emergence of influenza A virusesSequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genesGeneration of high-yielding influenza A viruses in African green monkey kidney (Vero) cells by reverse geneticsCross-Species Virus Transmission and the Emergence of New Epidemic DiseasesAnalysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells.An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase.The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014.Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza virusesAdaptation of avian influenza A virus polymerase in mammals to overcome the host species barrierRole of quail in the interspecies transmission of H9 influenza A viruses: molecular changes on HA that correspond to adaptation from ducks to chickensBovine parainfluenza virus type 3 (BPIV3) fusion and hemagglutinin-neuraminidase glycoproteins make an important contribution to the restricted replication of BPIV3 in primates.Phylogenetic analysis of the entire genome of influenza A (H3N2) viruses from Japan: evidence for genetic reassortment of the six internal genes.A recombinant human parainfluenza virus type 3 (PIV3) in which the nucleocapsid N protein has been replaced by that of bovine PIV3 is attenuated in primates.Recombinant bovine/human parainfluenza virus type 3 (B/HPIV3) expressing the respiratory syncytial virus (RSV) G and F proteins can be used to achieve simultaneous mucosal immunization against RSV and HPIV3.Mucosal immunization of rhesus monkeys against respiratory syncytial virus subgroups A and B and human parainfluenza virus type 3 by using a live cDNA-derived vaccine based on a host range-attenuated bovine parainfluenza virus type 3 vector backboneEnhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes.Identification of human H1N2 and human-swine reassortant H1N2 and H1N1 influenza A viruses among pigs in Ontario, Canada (2003 to 2005).Determinants of the host range restriction of replication of bovine parainfluenza virus type 3 in rhesus monkeys are polygenic.Multiple genome segments determine virulence of bluetongue virus serotype 8Genetically engineered live attenuated influenza A virus vaccine candidatesRescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation.A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.Use of PCR-enzyme immunoassay for identification of influenza A virus matrix RNA in clinical samples negative for cultivable virus.PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigsEvidence for a novel gene associated with human influenza A viruses.Comparisons of highly virulent H5N1 influenza A viruses isolated from humans and chickens from Hong Kong.Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase.Principles underlying rational design of live attenuated influenza vaccines.Nectin-4 Interactions Govern Measles Virus Virulence in a New Model of Pathogenesis, the Squirrel Monkey (Saimiri sciureus).NP, PB1, and PB2 viral genes contribute to altered replication of H5N1 avian influenza viruses in chickens.Influenza Virus: A Master Tactician in Innate Immune Evasion and Novel Therapeutic Interventions.Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses.
P2860
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P2860
Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Use of single-gene reassortant ...... ys and adult human volunteers.
@en
Use of single-gene reassortant ...... ys and adult human volunteers.
@nl
type
label
Use of single-gene reassortant ...... ys and adult human volunteers.
@en
Use of single-gene reassortant ...... ys and adult human volunteers.
@nl
prefLabel
Use of single-gene reassortant ...... ys and adult human volunteers.
@en
Use of single-gene reassortant ...... ys and adult human volunteers.
@nl
P2093
P2860
P1476
Use of single-gene reassortant ...... ys and adult human volunteers.
@en
P2093
B R Murphy
E K Subbarao
M L Clements
R A Karron
W T London
P2860
P304
P407
P577
1992-03-01T00:00:00Z