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The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalizationThe G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub componentsThe impact of GPCR structures on pharmacology and structure-based drug designReceptor heteromerization and drug discovery.Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapesThe concept of allosteric interaction and its consequences for the chemistry of the brainStructure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptorsFluorescent approaches for understanding interactions of ligands with G protein coupled receptorsExpression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoaDimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced DissociationCrosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integrationOn the fitting of binding data when receptor dimerization is suspected.The triplet puzzle of homologies in receptor heteromers exists also in other types of protein-protein interactions.Leukotriene BLT2 receptor monomers activate the G(i2) GTP-binding protein more efficiently than dimersEndothelin receptors: what's new and what do we need to know?Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization.Design strategies for bivalent ligands targeting GPCRs.Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerizationOligomerisation of C. elegans olfactory receptors, ODR-10 and STR-112, in yeast.Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 bindingArrestin-rhodopsin binding stoichiometry in isolated rod outer segment membranes depends on the percentage of activated receptors.Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer.Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imagingAn analysis of oligomerization interfaces in transmembrane proteins.Structural basis of M3 muscarinic receptor dimer/oligomer formationOccupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.The functional cycle of visual arrestins in photoreceptor cells.Synthesis of novel triplets with a 1,3,5-trioxazatriquinane skeleton and their pharmacologies for opioid receptors.Domain coupling in GPCRs: the engine for induced conformational changesManipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestinsMonitoring endosomal trafficking of the g protein-coupled receptor somatostatin receptor 3.The prevalence, maintenance, and relevance of G protein-coupled receptor oligomerizationGlobal Mapping of O-Glycosylation of Varicella Zoster Virus, Human Cytomegalovirus, and Epstein-Barr Virus.Rich tapestry of G protein-coupled receptor signaling and regulatory mechanisms.Oligomerization of DHHC protein S-acyltransferases.Modelling the interdependence between the stoichiometry of receptor oligomerization and ligand binding for a coexisting dimer/tetramer receptor system.Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevanceG protein-coupled receptor hetero-dimerization: contribution to pharmacology and function.GPCR dimers fall apart.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
How and why do GPCRs dimerize?
@en
How and why do GPCRs dimerize?
@nl
type
label
How and why do GPCRs dimerize?
@en
How and why do GPCRs dimerize?
@nl
prefLabel
How and why do GPCRs dimerize?
@en
How and why do GPCRs dimerize?
@nl
P2860
P1476
How and why do GPCRs dimerize?
@en
P2093
Eugenia V Gurevich
Vsevolod V Gurevich
P2860
P304
P356
10.1016/J.TIPS.2008.02.004
P577
2008-04-01T00:00:00Z