Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration.
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Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axonsNMNAT1 mutations cause Leber congenital amaurosisGuidance molecules in axon pruning and cell deathMutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degenerationProtective effects and mechanisms of sirtuins in the nervous systemWallerian degeneration: the innate-immune response to traumatic nerve injuryThe Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat proteinMutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophyWld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NADMislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from PellagraAxon degeneration: Molecular mechanisms of a self-destruction pathwayMammalian sirtuins: biological insights and disease relevanceWallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning.Wallerian-like degeneration of central neurons after synchronized and geometrically registered mass axotomy in a three-compartmental microfluidic chipA novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity.Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivoA rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degenerationOverexpression of Wld(S) or Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish.Novel compound heterozygous NMNAT1 variants associated with Leber congenital amaurosis.Rapid in vivo forward genetic approach for identifying axon death genes in DrosophilaClinical progression in Parkinson disease and the neurobiology of axons.Wallerian degeneration, wld(s), and nmnat.Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose.Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration.Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.Intracellular signalling pathways in dopamine cell death and axonal degeneration.A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruningSpy1 Protein Mediates Phosphorylation and Degradation of SCG10 Protein in Axonal Degeneration.Live Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx.WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.Axon degeneration in Parkinson's diseaseThe Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.Local axonal protection by WldS as revealed by conditional regulation of protein stability.SCG10 is a JNK target in the axonal degeneration pathway.Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in DrosophilaNicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response.Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in miceMaintaining energy homeostasis is an essential component of Wld(S)-mediated axon protection.
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P2860
Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Wld S requires Nmnat1 enzymati ...... ppress Wallerian degeneration.
@en
Wld S requires Nmnat1 enzymati ...... ppress Wallerian degeneration.
@nl
type
label
Wld S requires Nmnat1 enzymati ...... ppress Wallerian degeneration.
@en
Wld S requires Nmnat1 enzymati ...... ppress Wallerian degeneration.
@nl
prefLabel
Wld S requires Nmnat1 enzymati ...... ppress Wallerian degeneration.
@en
Wld S requires Nmnat1 enzymati ...... ppress Wallerian degeneration.
@nl
P2093
P2860
P356
P1476
Wld S requires Nmnat1 enzymati ...... ppress Wallerian degeneration.
@en
P2093
Amy E Sheehan
Kimberly S Kerr
Marc R Freeman
Michelle A Avery
P2860
P304
P356
10.1083/JCB.200808042
P407
P577
2009-02-01T00:00:00Z