Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. - Wikidata - wikimedia - TriplyDB

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse.

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse.

http://www.wikidata.org/entity/Q37128350

about

The tuberous sclerosis complex Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function Astrocytes conspire with neurons during progression of neurological disease Autism spectrum disorders and neuropathology of the cerebellum Stochastic model of Tsc1 lesions in mouse brain Radial glia: progenitor, pathway, and partner Both maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+/-) mice.Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice The apical complex couples cell fate and cell survival to cerebral cortical development.Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex.GABAergic interneuron development and function is modulated by the Tsc1 gene.Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits Mechanism-based treatment in tuberous sclerosis complex.Sleep, plasticity and the pathophysiology of neurodevelopmental disorders: the potential roles of protein synthesis and other cellular processes.Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network.mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis.STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis.Rheb1 is required for mTORC1 and myelination in postnatal brain development Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy.Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration mTOR regulates brain morphogenesis by mediating GSK3 signaling.Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis.Frontier of epilepsy research - mTOR signaling pathway.Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis.Tuberous sclerosis complex: everything old is new again.mTOR signaling in epilepsy: insights from malformations of cortical development Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities.Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation.Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling.Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion.

P2860

Q24628011-1F223AD2-952A-40B4-9F6C-F3584095384A Q26770762-6A1C9C92-073A-402C-9E15-751220E0025B Q26852070-C20703AD-3A40-4250-954D-5AA31B14A81A Q26853603-575A82D1-21DA-4099-8557-47E828C8661D Q27319406-A5226478-D2AE-4B79-AE67-AAB9629AEEEA Q28237232-D06BA1D5-B76D-4C83-AF59-E863FA81FA23 Q30432308-54D72173-BEC6-4077-BDAD-BA8AE709574D Q30444988-0514BEC2-3D19-4C63-BBD6-DE0D4F8C9CF5 Q30494549-C2DE67B2-302F-400D-9E11-5E586A33E7A9 Q30497818-98AD94D9-126C-4845-A9DE-C36B413A4B06 Q30499302-F688495F-AFB7-44FB-91A1-1F3C25D7F8AC Q30518266-87016A8B-E8F0-4294-8349-52FEF9EB2404 Q30523993-AB69F27E-6E71-43BC-9311-AC4B7FB4FED5 Q30543921-61FB14E3-CD68-4489-91A5-16CC83A82D90 Q30586288-E226D6A2-761F-45F1-8C19-CF4D29224162 Q30597707-CDE6D3C6-4DF2-4882-9B0E-A0FD499E685B Q30746587-DD2F7C4F-11AE-44EF-BBC5-B3EE87555525 Q30823493-8B21A9D4-728C-41EC-9B8B-FADEBD18E848 Q30837882-372EDC8A-582C-4D2C-B9DB-13B1B2401D98 Q33573231-7E3CCAFD-B058-4364-A437-929E3F5C8BE8 Q33750454-8854EBCD-0597-4DA9-B98B-C92876AAA4C4 Q33815644-7391D131-D49F-4075-9AF0-2CCC29C37790 Q34427606-B3D22CC1-8CB0-4581-BC7C-93A0E6D6F555 Q34569989-661A161C-CF00-4953-9B03-1829526A042A Q34665970-8FC86F3A-7F44-4607-8338-C59CE405D70F Q34778218-0C09B896-0450-4236-9C47-86E1BC55D0CE Q34987845-860FB186-6783-418F-86EA-3D8875B36A5E Q34999217-71CC536C-9BDD-4F65-86A9-79703CB09467 Q35009587-FB78DFB6-0ACC-42D6-8AD3-929B0171CA06 Q35014198-B3842F36-46E4-4809-87FC-542FE4D7BDBD Q35024472-AA25A784-ABF5-4D77-9B7A-2BDD1DF56C8F Q35187265-B10F92F8-8BD5-4B86-8FAD-E81A0F744229 Q35245211-93C4FC7B-52E5-4698-9317-3EED8DDE5FDA Q35248484-12EAC855-ABF0-4875-8E5B-6F51B8637179 Q35278772-7C4AC77A-C5E6-49D1-9158-ABC3A08A33AF Q35476371-F7072774-2B9F-4705-B658-21F8A14946BF Q35532932-B73DB26E-5FAD-4498-962C-E2E0FD34E57B Q35546651-1537263E-E4F5-4838-814C-C7BC963E0F3F Q35610474-6EED9642-DBE4-4F2D-BCFC-FC4709448578 Q35688636-7F23BC2A-DD25-4D51-838C-4190B1FD725F

P2860

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse.

http://www.wikidata.org/entity/Q37128350

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 15 January 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.

@en

Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.

@nl

type

label

Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.

@en

Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.

@nl

prefLabel

Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.

@en

Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.

@nl

P1433

Q37128350-69ED28EC-F794-4327-A9E0-B0AAC03883AC

P1476

Q37128350-088364EE-D9E7-45EA-88FD-D0BF2CAC4D35

P2093

Q37128350-2211C4DA-DED5-430D-833F-17E0540FF202

Q37128350-4DE91730-13E9-4127-819C-FBD025F904A0

Q37128350-906488AB-6552-4FF7-A479-29DE449793A7

Q37128350-CCB739D5-7B65-4238-99E4-18761F88336D

Q37128350-DEAFE37E-9F20-49EE-964A-D7ABD4BFA5B6

Q37128350-F70B9F53-61F8-49E9-B0E6-1881A274E3C6

P2860

Q37128350-00AA9D8D-37D6-4A3A-839D-950E4EE2A88D

Q37128350-030E5727-F612-477A-8FE2-CEA53BC8CC8E

Q37128350-03B9AE28-1F3D-4930-AF6D-9F50B23DEAA8

Q37128350-06985BF4-D4E7-4856-B991-0C047A5BCE60

Q37128350-0B623514-0F6B-4607-8300-5C37F94FCB21

Q37128350-1053FC33-B8F5-45D7-BF49-A3D03DEE5B32

Q37128350-13A07B7A-D21C-4727-BD6B-64D5686D414B

Q37128350-158636A3-6760-48E7-B31A-98304DEEA179

Q37128350-193FD828-C3FD-4217-91BA-F9DAD3983776

Q37128350-19B2EC62-8727-4624-BC54-421ECC3FF4BC

P304

Q37128350-D4103F6C-5964-4AEE-AF81-48EA90513C9E

P31

Q37128350-6F31561A-077A-4FFE-A97E-DD5C5B662D6B

P356

Q37128350-4DB52489-F296-41C6-B655-C570B44CE21E

P433

Q37128350-7D6F42BF-EC7A-4E99-BF89-BD4D22262FCB

P478

Q37128350-9EBDF824-5218-4E82-AC44-0EB27B3D30E8

P577

Q37128350-30E752C3-6FA1-4D3B-9CD0-3DA0B7DB8CEA

P5875

Q37128350-C19C3AD5-E8D4-498A-972E-E4C17F4027FC

P698

Q37128350-C03F5E62-79EB-4797-8952-29A47E163C2E

P921

Q37128350-87366124-1276-403d-82fd-44bcc53176cf

Q37128350-CD61EB72-2DE5-4A32-8D70-3B3A4ACCF008

P932

Q37128350-BE6D6729-F6CD-4FD9-8EA5-9470220E1740

P356

P1433

Human Molecular Genetics

P1476

Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.

@en

P2093

Henry Cheng-Ju Wu

http://www.w3.org/2001/XMLSchema#string

James McKenna

http://www.w3.org/2001/XMLSchema#string

Michael J Gambello

http://www.w3.org/2001/XMLSchema#string

R Michelle Reith

http://www.w3.org/2001/XMLSchema#string

Sharon W Way

http://www.w3.org/2001/XMLSchema#string

Ulrike Mietzsch

http://www.w3.org/2001/XMLSchema#string

P2860

Wrapping it up: the cell biology of myelination

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis.

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

Neurons derived from radial glial cells establish radial units in neocortex

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

P304

1252-1265

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/HMG/DDP025

http://www.w3.org/2001/XMLSchema#string

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

18

http://www.w3.org/2001/XMLSchema#string

P577

2009-01-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23798071

http://www.w3.org/2001/XMLSchema#string

P698

19150975

http://www.w3.org/2001/XMLSchema#string

P921

P932

2655769

http://www.w3.org/2001/XMLSchema#string