Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse.
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The tuberous sclerosis complexRibosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to FunctionAstrocytes conspire with neurons during progression of neurological diseaseAutism spectrum disorders and neuropathology of the cerebellumStochastic model of Tsc1 lesions in mouse brainRadial glia: progenitor, pathway, and partnerBoth maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+/-) mice.Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 miceThe apical complex couples cell fate and cell survival to cerebral cortical development.Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in miceThe differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex.GABAergic interneuron development and function is modulated by the Tsc1 gene.Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficitsMechanism-based treatment in tuberous sclerosis complex.Sleep, plasticity and the pathophysiology of neurodevelopmental disorders: the potential roles of protein synthesis and other cellular processes.Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network.mTORC1 signaling and primary cilia are required for brain ventricle morphogenesisFrom mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis.STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and miceThe small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis.Rheb1 is required for mTORC1 and myelination in postnatal brain developmentRapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy.Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degenerationmTOR regulates brain morphogenesis by mediating GSK3 signaling.Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis.Frontier of epilepsy research - mTOR signaling pathway.Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis.Tuberous sclerosis complex: everything old is new again.mTOR signaling in epilepsy: insights from malformations of cortical developmentEpileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities.Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation.Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling.Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion.
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Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.
@en
Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.
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type
label
Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.
@en
Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.
@nl
prefLabel
Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.
@en
Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.
@nl
P2093
P2860
P356
P1476
Loss of Tsc2 in radial glia mo ...... clerosis complex in the mouse.
@en
P2093
Henry Cheng-Ju Wu
James McKenna
Michael J Gambello
R Michelle Reith
Sharon W Way
Ulrike Mietzsch
P2860
P304
P356
10.1093/HMG/DDP025
P577
2009-01-15T00:00:00Z