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Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

http://www.wikidata.org/entity/Q37128812

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Challenges and Current Efforts in the Development of Biomarkers for Chronic Inflammatory and Remodeling Conditions of the Lungs Stable long-term cultures of self-renewing B cells and their applications The impact of viral genotype on pathogenesis and disease severity: respiratory syncytial virus and human rhinoviruses The role of dendritic cells and monocytes in the maintenance and loss of respiratory tolerance Rhinovirus and childhood asthma: an update Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention Respiratory viral infections and host responses; insights from genomics Rhinovirus-Induced Airway Disease: A Model to Understand the Antiviral and Th2 Epithelial Immune Dysregulation in Childhood Asthma Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis Immune-mediated diseases and microbial exposure in early life.Multicenter study of viral etiology and relapse in hospitalized children with bronchiolitis.Disaggregating asthma: Big investigation versus big data.Update in asthma 2013 Recent advances in understanding lung function development The lung microbiome. A new frontier in pulmonary medicine.Early-life viral infections and the development of asthma: a target for asthma prevention?Infection-induced wheezing in young children Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop Infection-related asthma.Association between 17q12-21 variants and asthma in Japanese women: rs11650680 polymorphism as potential genetic marker for asthma.Risks for infection in patients with asthma (or other atopic conditions): is asthma more than a chronic airway disease?Deciphering the tête-à-tête between the microbiota and the immune system.Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.Early life environmental predictors of asthma age-of-onset Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus Toward primary prevention of asthma. Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma Is asthma an infectious disease? New evidence.Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation.Infections and their role in childhood asthma inception Sphingolipid metabolites in inflammatory disease.The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis Host genetic variation influences gene expression response to rhinovirus infection Disseminated rhinovirus C8 infection with infectious virus in blood and fatal outcome in a child with repeated episodes of bronchiolitis.Comparison of temporal transcriptomic profiles from immature lungs of two rat strains reveals a viral response signature associated with chronic lung dysfunction Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort.From bronchiolitis guideline to practice: A critical care perspective eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function.Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

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Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

http://www.wikidata.org/entity/Q37128812

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article científic

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 March 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

@en

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.

@nl

type

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Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

@en

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.

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prefLabel

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

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Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.

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The New England Journal of Medicine

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Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

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Daniel J Jackson

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Eskil Kreiner-Møller

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James E Gern

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Michelle M Stein

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Minal Calışkan

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ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

A large-scale, consortium-based genomewide association study of asthma

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study.

Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes

Prenatal and postnatal environmental tobacco smoke exposure and children's health.

A sequence variant on 17q21 is associated with age at onset and severity of asthma.

Gene-environment interactions in human disease: nuisance or opportunity?

Effect of 17q21 variants and smoking exposure in early-onset asthma.

Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.

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1398-1407

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scholarly article

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10.1056/NEJMOA1211592

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15

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368

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Eskil Kreiner-Møller

Klaus Bønnelykke

Robert F Lemanske

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2013-03-27T00:00:00Z

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23534543

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3755952

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