Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. - Wikidata - wikimedia - TriplyDB

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

http://www.wikidata.org/entity/Q37129434

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Alzheimer's disease as homeostatic responses to age-related myelin breakdown The Rationale for Insulin Therapy in Alzheimer's Disease Type 2 diabetes and cognitive impairment: linking mechanisms Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions AMPK: a cellular metabolic and redox sensor. A minireview Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease Drug repositioning approaches for the discovery of new therapeutics for Alzheimer's disease Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex Role of anti-diabetic drugs as therapeutic agents in Alzheimer's disease Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice Effects of AMP-activated protein kinase in cerebral ischemia Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels-An Ex Vivo Study.AMPK activation--protean potential for boosting healthspan.AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats.Diabetes and the brain: issues and unmet needs.To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease.Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans.Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators.Metformin in the diabetic brain: friend or foe?Diabetes, related conditions, and dementia.Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling Increased risk of affective disorders in type 2 diabetes is minimized by sulfonylurea and metformin combination: a population-based cohort study Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis Differential regulation of BACE1 expression by oxidative and nitrosative signals AMPK at the nexus of energetics and aging.Insulin suppresses the expression of amyloid precursor protein, presenilins, and glycogen synthase kinase-3beta in peripheral blood mononuclear cells.Obesity, insulin resistance, and Alzheimer's disease.Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease.Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases

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Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

http://www.wikidata.org/entity/Q37129434

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bilimsel makale

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scientific article published on 23 February 2009

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vetenskaplig artikel

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Antidiabetic drug metformin (G ...... egulating BACE1 transcription.

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Antidiabetic drug metformin

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Antidiabetic drug metformin (G ...... egulating BACE1 transcription.

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Antidiabetic drug metformin

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Antidiabetic drug metformin (G ...... egulating BACE1 transcription.

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PNAS.0807991106

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Proceedings of the National Academy of Sciences of the United States of America

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Antidiabetic drug metformin (G ...... regulating BACE1 transcription

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Francesca-Fang Liao

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Huaxi Xu

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Kun Zhou

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Robert C Thompson

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Ruishan Wang

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Tao Ma

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Yaomin Chen

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Yongbo Zhao

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Young-Don Kwak

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Yun Liu

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P2860

Mechanism by which metformin reduces glucose production in type 2 diabetes

Role of AMP-activated protein kinase in mechanism of metformin action

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.

Insulin and cognitive function in humans: experimental data and therapeutic considerations.

Cellular and molecular basis of beta-amyloid precursor protein metabolism.

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.

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3907-3912

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scholarly article

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10.1073/PNAS.0807991106

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10

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Laura Gasparini

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2009-02-23T00:00:00Z

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24035248

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Alzheimer's disease

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