FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
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Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradationThe evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXONew advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseasesC. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stressThe forkhead transcription factor Hcm1 promotes mitochondrial biogenesis and stress resistance in yeast.Role of farnesoid X receptor and bile acids in alcoholic liver diseaseMitochondria and FOXO3: breath or dieAnimal models and conserved processesExcess Maternal Fructose Consumption Increases Fetal Loss and Impairs Endometrial Decidualization in MiceFOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cellsCombined informatic and expression screen identifies the novel DAF-16 target HLH-13Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor.Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse modelResistance exercise, skeletal muscle FOXO3A, and 85-year-old womenEAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activityTranscription factor FoxO1 is essential for enamel biomineralization.FoxOs function synergistically to promote glucose production.Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila modelTargeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models.Foxo: in command of T lymphocyte homeostasis and tolerance.Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene.Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.A new DAF-16 isoform regulates longevity.Converging pathways in lifespan regulationAssociation study of FOXO3A SNPs and aging phenotypes in Danish oldest-old individuals.FHIT gene expression is repressed by mitogenic signaling through the PI3K/AKT/FOXO pathway.FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary diseaseUnraveling the role of FoxOs in bone--insights from mouse models.A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development.FoxO1, the transcriptional chief of staff of energy metabolism.Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer.FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastomaMicroRNA and mRNA Transcriptome Profiling in Primary Human Astrocytes Infected with Borrelia burgdorferiAging mechanisms in bone.FOXO3a inhibits TNF-α- and IL-1β-induced astrocyte proliferation:Implication for reactive astrogliosisFOXO1-mediated activation of Akt plays a critical role in vascular homeostasis.Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase.FOXO3a promotes gastric cancer cell migration and invasion through the induction of cathepsin L.Regulation of fat cell mass by insulin in Drosophila melanogaster
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FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on April 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
@en
FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
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FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
@en
FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
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FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
@en
FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
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FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.
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10.1038/ONC.2008.27
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2008-04-01T00:00:00Z