The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
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Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaDecreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell functionImpaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDMDysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesDiabetes outfoxed by GLP-1?Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body compositionFoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissueInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeA Foxo/Notch pathway controls myogenic differentiation and fiber type specificationMechanisms of action of glucagon-like peptide 1 in the pancreasConditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitusGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesForkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathyInteraction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathwayRictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell sizeFrom estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applicationsShifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndromeNov/Ccn3, a novel transcriptional target of FoxO1, impairs pancreatic β-cell functionDisruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversificationModeling integrated cellular machinery using hybrid Petri-Boolean networksThe B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stressDifferential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expressionEnhanced beta-cell mass without increased proliferation following chronic mild glucose infusionRole of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growthRegulation of the insulin gene by glucose and fatty acidsInhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathwayA feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.β-Cell regeneration mediated by human bone marrow mesenchymal stem cells.Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistanceFoxO gene family evolution in vertebrates.FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in miceFOXO transcription factors: their clinical significance and regulation.Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R SignalingGlucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinasesRegulation of pancreatic β-cell function and mass dynamics by prostaglandin signaling.Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodentsTranscription Factor Forkhead Regulates Expression of Antimicrobial Peptides in the Tobacco Hornworm, Manduca sexta
P2860
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P248
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P2860
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Dezember 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/12/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/12/01)
@nl
наукова стаття, опублікована в грудні 2002
@uk
مقالة علمية (نشرت في ديسمبر 2002)
@ar
name
The forkhead transcription fac ...... of pancreatic beta cell growth
@ast
The forkhead transcription fac ...... of pancreatic beta cell growth
@en
The forkhead transcription fac ...... of pancreatic beta cell growth
@nl
type
label
The forkhead transcription fac ...... of pancreatic beta cell growth
@ast
The forkhead transcription fac ...... of pancreatic beta cell growth
@en
The forkhead transcription fac ...... of pancreatic beta cell growth
@nl
prefLabel
The forkhead transcription fac ...... of pancreatic beta cell growth
@ast
The forkhead transcription fac ...... of pancreatic beta cell growth
@en
The forkhead transcription fac ...... of pancreatic beta cell growth
@nl
P2093
P2860
P921
P3181
P1476
The forkhead transcription fac ...... of pancreatic beta cell growth
@en
P2093
Christopher V. E. Wright
Karen C. Arden
Morris F. White
Tadahiro Kitamura
William H. Biggs
Yoshiaki Kido
Yukari Kitamura
P2860
P304
P3181
P356
10.1172/JCI16857
10.1172/JCI200216857
P407
P577
2002-12-01T00:00:00Z