Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.

Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.

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http://www.wikidata.org/entity/Q37132142
Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRsPathogen-inspired drug delivery to the central nervous system.Monkey adrenal chromaffin cells express α6β4* nicotinic acetylcholine receptorsStructural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes.α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells.From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR.The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptorsα9-containing nicotinic acetylcholine receptors and the modulation of pain.The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypesHeterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors.TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors.Human nicotinic receptors in chromaffin cells: characterization and pharmacology.Therapeutic concentrations of varenicline in the presence of nicotine increase action potential firing in human adrenal chromaffin cells.
P2860

Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.

Item
http://www.wikidata.org/entity/Q37132142
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 July 2013
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Positional scanning mutagenesi ...... tinic acetylcholine receptors.
@en
Positional scanning mutagenesi ...... tinic acetylcholine receptors.
@nl
type
label
Positional scanning mutagenesi ...... tinic acetylcholine receptors.
@en
Positional scanning mutagenesi ...... tinic acetylcholine receptors.
@nl
prefLabel
Positional scanning mutagenesi ...... tinic acetylcholine receptors.
@en
Positional scanning mutagenesi ...... tinic acetylcholine receptors.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
Positional scanning mutagenesi ...... tinic acetylcholine receptors.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932