A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors.
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Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?Characterization of a Novel α-Conotoxin TxID from Conus textile That Potently Blocks Rat α3β4 Nicotinic Acetylcholine ReceptorsA novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 3 2 vs. 6/ 3 2 3 nicotinic acetylcholine receptorsStructure-Function Elucidation of a New -Conotoxin, Lo1a, from Conus longurionisResidues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRsPositive modulation of the α9α10 nicotinic cholinergic receptor by ascorbic acid.The efferent medial olivocochlear-hair cell synapse.Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.Conotoxins targeting nicotinic acetylcholine receptors: an overviewAtypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor.Chemical synthesis and characterization of two α4/7-conotoxinsNicotinic receptor antagonists as treatments for nicotine abuse.Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channelsAlanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist.Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library.Molecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptor.Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins.Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes.A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype.Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptorsAlpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors.alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors.High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencingTargeting the alpha9alpha10 nicotinic acetylcholine receptor to treat severe pain.Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors.Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells.Alpha9 nicotinic acetylcholine receptors and the treatment of pain.Nicotinic receptor-based therapeutics and candidates for smoking cessation.Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.From toxins targeting ligand gated ion channels to therapeutic molecules.Design of new α-conotoxins: from computer modeling to synthesis of potent cholinergic compounds.α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors.Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors.α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn't.
P2860
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P2860
A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A novel alpha-conotoxin, PeIA, ...... cotinic cholinergic receptors.
@ast
A novel alpha-conotoxin, PeIA, ...... cotinic cholinergic receptors.
@en
type
label
A novel alpha-conotoxin, PeIA, ...... cotinic cholinergic receptors.
@ast
A novel alpha-conotoxin, PeIA, ...... cotinic cholinergic receptors.
@en
prefLabel
A novel alpha-conotoxin, PeIA, ...... cotinic cholinergic receptors.
@ast
A novel alpha-conotoxin, PeIA, ...... cotinic cholinergic receptors.
@en
P2093
P356
P1476
A novel alpha-conotoxin, PeIA, ...... cotinic cholinergic receptors.
@en
P2093
A Belén Elgoyhen
Baldomero M Olivera
J Michael McIntosh
Maren Watkins
María E Gomez-Casati
Paola V Plazas
P304
30107-30112
P356
10.1074/JBC.M504102200
P407
P577
2005-06-27T00:00:00Z