about
Computational methods in drug discoveryRapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL KinaseParallel synthesis of a library of symmetrically- and dissymmetrically-disubstituted imidazole-4,5-dicarboxamides bearing amino acid esters.An integrated drug-likeness study for bicyclic privileged structures: from physicochemical properties to in vitro ADME properties.Constrained bithiazoles: small molecule correctors of defective ΔF508-CFTR protein trafficking.High-throughput virtual screening of phloroglucinol derivatives against HIV-reverse transcriptase.DrugMint: a webserver for predicting and designing of drug-like molecules.Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting.How proteins bind macrocycles.Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery.Physicochemical Profiles of the Marketed Agrochemicals and Clues for Agrochemical Lead Discovery and Screening Library Development.Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.A systems biology approach to uncovering pharmacological synergy in herbal medicines with applications to cardiovascular disease.Clustered distribution of natural product leads of drugs in the chemical space as influenced by the privileged target-sites.Carboxylate derivatives of tributyltin (IV) complexes as anticancer and antileishmanial agents.N-aryl pyrazoles, indazoles and azaindazoles as antagonists of CC chemokine receptor 1: patent cooperation treaty applications WO2010/036632, WO2009/134666 and WO2009/137338.Chemodiversity and molecular plasticity: recognition processes as explored by property spaces.Chemical predictive modelling to improve compound quality.Design, synthesis and antitubercular activity of certain nicotinic Acid hydrazides.Synthesis, antiproliferative activity and molecular properties predictions of galloyl derivatives.Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours.Towards a more robust approach to selecting and prosecuting promising targets and compounds.Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety.In Silico and In Vitro Anticancer Activity of Isolated Novel Marker Compound from Chemically Modified Bioactive Fraction from Curcuma longa (NCCL).Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs.Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.Systems pharmacology analysis of synergy of TCM: an example using saffron formula.Predicting the physicochemical profile of diastereoisomeric histidine-containing dipeptides by property space analysis.Overview of high-throughput screening.Effects of 1,3,5-triphenyl-4,5-dihydro-1H-pyrazole derivatives on cell-cycle and apoptosis in human acute leukemia cell lines.A Comparative Study on the Constitutive Properties of Marketed Pesticides.Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3,4-methylenedioxybenzoyl-2-thienylhydrazoneIn Silico ADME/Tox PredictionsUnderstanding drug-likeness
P2860
Q26997089-CC27C587-8BB9-424C-9305-3919BA8A7F24Q30382639-DBE2F4F7-9C5F-4D05-B4BD-A5B8ABEA4CB5Q33399944-C8827C49-06C3-42B9-9C96-8E204312CD6DQ33888168-04DFB9E4-788B-4709-A3A7-74F7FE625D73Q34061088-A72B76C9-D053-4244-9E3A-65B9CD937B43Q34556651-59A0B797-31ED-40C9-8E78-675C8E4564D4Q35031360-9E4B315B-6A30-4F2D-8D2C-D80DB2B0AAB3Q35149474-FBB26DAD-B5A7-488A-96AA-8ED045AB74F8Q35209183-7B5A863A-1FCD-4E87-8BA5-65E445A63AAEQ35631111-336EBE17-A5AD-48EB-8DCC-B88DD359CAB7Q36094830-54753CD0-A67B-4398-8E7C-98F881DCC0D7Q36156057-64B79116-0E05-4DCF-9BD0-B2FF28D539DBQ36457923-D6F7F3E5-CC1D-4737-92DC-5B456B6B16F9Q37737158-0583CAEC-5237-427C-83D4-D670D5CA69B2Q37737964-1EC510EB-696B-45C1-869F-E18B7BEB2B70Q37790697-493905C2-07C1-41DD-9EEF-80B9673AEEAFQ37894716-588EABDA-1D65-4281-A1F5-8E3C4C96EAA2Q38167262-397D4B69-515B-4B5B-AB13-66ABF01D64ACQ38873225-E833DCB2-064E-4CC7-A36B-01D386DF81BCQ38894243-29E2B6C5-17B2-49DF-903E-89AC9A0CFBD4Q39811801-DBCB47BE-F579-4178-8987-F33AE9A5F3F2Q39915228-A5E0CC55-62C2-4A83-AD36-8F9575040769Q43062383-7A7E304B-148E-4A45-B64E-BBB9BC3CE4C0Q47103670-CDA96ED0-B9FA-4453-B2F1-CEDC23005EFFQ47324655-0C46A2AA-153A-4550-8511-C0E0FFC09246Q48362157-3D8FFA8C-B977-4112-8A7A-956D50E1421EQ49190788-7CCFB696-6570-4358-AD19-1BE49D390EE4Q51370621-050F3025-2E9F-4038-B36A-33A940EDBB36Q51850527-F3A60459-A710-42A4-BC9B-D0B19B654F1EQ52793168-078D33E9-E6D9-4E58-AB63-042BD7DBE350Q52854485-E5353D3D-FA71-4980-83D3-762005F178F5Q56514700-68789757-8D74-4999-B5D0-3FED097052A2Q56984194-AB866C67-B220-4357-A328-3C39B7FE39DEQ57016955-C00FF44F-ADD7-48AD-B4CE-47316ACE3226
P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Assessing drug-likeness--what are we missing?
@en
Assessing drug-likeness--what are we missing?
@nl
type
label
Assessing drug-likeness--what are we missing?
@en
Assessing drug-likeness--what are we missing?
@nl
prefLabel
Assessing drug-likeness--what are we missing?
@en
Assessing drug-likeness--what are we missing?
@nl
P1433
P1476
Assessing drug-likeness--what are we missing?
@en
P2093
Alessandro Pedretti
Bernard Testa
P304
P356
10.1016/J.DRUDIS.2007.11.007
P577
2008-01-16T00:00:00Z