Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. - Wikidata - wikimedia - TriplyDB

Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.

Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.

http://www.wikidata.org/entity/Q37141510

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Targeting the Mitotic Catastrophe Signaling Pathway in Cancer Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer Multimodal effects of small molecule ROCK and LIMK inhibitors on mitosis, and their implication as anti-leukemia agents.Expression and function analysis of mitotic checkpoint genes identifies TTK as a potential therapeutic target for human hepatocellular carcinoma.Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.Mps1 kinase regulates tumor cell viability via its novel role in mitochondria Modulation of miR-21 signaling by MPS1 in human glioblastoma TTK is a favorable prognostic biomarker for triple-negative breast cancer survival.Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer.Molecular and genetic pathways in gliomas: the future of personalized therapeutics.Targeting mitotic pathways for endocrine-related cancer therapeutics.Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.Molecular basis underlying resistance to Mps1/TTK inhibitors.TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.CRM197 in Combination With shRNA Interference of VCAM-1 Displays Enhanced Inhibitory Effects on Human Glioblastoma Cells.TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.Whole Exome Sequencing Identify the 6q12-q16 Linkage Region and a Candidate Gene TTK for Pulmonary Nontuberculous Mycobacterial Disease.Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers.Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer.Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2).The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1.Mps1/TTK: a novel target and biomarker for cancer.Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.Targeting the cell cycle in breast cancer: towards the next phase Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N-neopentyl

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Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.

http://www.wikidata.org/entity/Q37141510

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 12 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Effects of the selective MPS1 ...... sitivity to antimitotic drugs.

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Effects of the selective MPS1 ...... sitivity to antimitotic drugs.

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Effects of the selective MPS1 ...... sitivity to antimitotic drugs.

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Effects of the selective MPS1 ...... sitivity to antimitotic drugs.

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Effects of the selective MPS1 ...... sitivity to antimitotic drugs.

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Effects of the selective MPS1 ...... sitivity to antimitotic drugs.

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Journal of the National Cancer Institute

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Effects of the selective MPS1 ...... sitivity to antimitotic drugs.

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Almuth F Kessler

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Bakhos A Tannous

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Carsten Hagemann

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David P Noske

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Grant Lewandrowski

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Jinhua Wang

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Johanna M Niers

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Laurine Wedekind

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Lotte Hiddingh

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Mariam Kerami

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P2860

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase

The spindle-assembly checkpoint in space and time

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Mps1 kinase promotes sister-kinetochore bi-orientation by a tension-dependent mechanism

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1322-1331

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scholarly article

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10.1093/JNCI/DJT168

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17

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105

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Tonny Lagerweij

Philip C De Witt Hamer

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2013-08-12T00:00:00Z

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23940287

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3760778

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