The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
about
Lentiviral vectors in gene therapy: their current status and future potentialLentiviral vector gene therapy: effective and safe?Production of lentiviral vectorsCurrent and future alternative therapies for beta-thalassemia majorExperimental methods to preserve male fertility and treat male factor infertilityThe utility of transposon mutagenesis for cancer studies in the era of genome editing.Progress and prospects for engineered T cell therapiesHematopoietic stem cell gene therapy:assessing the relevance of preclinical modelsRetroviral integrations in gene therapy trialsHematopoietic stem cell engineering at a crossroadsGene therapy on the moveIs genetic rescue of cystinosis an achievable treatment goal?Identifying Cancer Driver Genes Using Replication-Incompetent Retroviral VectorsGene therapy for hemophiliaUncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivoGeneration of healthy mice from gene-corrected disease-specific induced pluripotent stem cellsAddressing biological uncertainties in engineering gene circuitsGene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?Gene therapy in the cornea: 2005--present.Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy.Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model.Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vectorGene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia.Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors.Towards a clinically relevant lentiviral transduction protocol for primary human CD34 hematopoietic stem/progenitor cells.Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases.Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells.Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.Update on gene therapy for immunodeficiencies.CRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient CellsGenome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells.Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.Gene therapy strategies: can we eradicate HIV?Site-specific gene insertion mediated by a Cre-loxP-carrying lentiviral vector.Gammaretroviral vectors: biology, technology and applicationMolecular mechanisms of retroviral integration site selection.High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones.Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.
P2860
Q24629462-800250DD-D137-4381-AF46-0910D57D6EEBQ24630888-03DD595E-08A4-4B56-8221-623F248EA013Q26750586-43BD0B3C-CFF5-40B7-93A5-1AD2FFE60F07Q26750906-CEAEA4A3-0AE1-4805-A07D-8C4BF1A498E4Q26770116-19FA0C13-756C-4A95-9980-E2312BBD4AB9Q26781762-25589AF3-5C89-46C0-B6A0-8A1B5E0541E5Q26852923-56D7B960-7812-4942-8AC4-CE14BA72548BQ26859147-9BD00E0F-3BFB-4EAE-926D-57C1B0237EBBQ26991660-68BAE2CF-5057-496C-8756-B22E382D9CBEQ27001570-B91E6DC0-3234-4D82-9A3B-7C49FA173824Q27007012-A5157957-EC56-4FF1-A9DE-0D39886B5CA4Q27023975-DA9F72EF-FEA8-4195-AF8F-C58528E147E7Q28077919-67E4ADBE-7B8A-4B65-82C9-890E460BBDBCQ28081911-EFEC5F1C-9395-44B3-8BC4-F725AF5BFF00Q28383769-6AD0FB64-8F2C-43FF-811E-57BC7FE7AD5DQ28478987-CA1FCB41-F856-4B6E-95BB-9DF1061C91C8Q28834528-74DC28FD-E274-4136-83F1-31F6AC522943Q30364488-6D1C8D53-40A7-4AD6-AB64-BEFC3B4EC4D3Q30459643-5CF17C8C-A71A-4A52-8A39-B3E32D40C7DAQ30531405-9CC8F1DF-707A-4BD5-840B-869629875F7AQ30541387-94A30AFC-B6F4-43B0-9CC7-9AEB855E0EF8Q31131479-A4353878-7345-4AC6-AB9F-B594DD810B17Q33386724-B9F07299-5DE9-4FF7-88CB-5CB484314F3DQ33408529-6D499E1D-67BC-436C-A362-979DC47B6CBEQ33489590-A7120111-29A7-467A-BC49-71A4FAC3D1ECQ33552027-03526324-B2AF-47B2-8451-51D741A588A2Q33713150-136CB03C-645C-4133-B6DD-637A8630D848Q33713156-55E9F615-3A25-4D18-AFEE-77460110727CQ33713196-F64F1EBC-F9AF-4751-8186-73EF2C3F7A23Q33798427-98F500D4-7A5E-4F66-8D56-A8CBD36F80CFQ33838956-25D67378-F0AF-4FF4-9E79-085E8C3D56F6Q33891707-6C28D80B-1533-4ABD-B3CA-22BB2CBC4941Q34019596-4BBE7137-2B01-4F08-91FC-F69065B76E61Q34074917-AE486640-657D-461C-8ED0-A3D63411C6FCQ34165454-DCC344DB-A6B6-4503-BCA5-FA35AD1D8EBBQ34183407-44679005-21E9-4C53-8D00-BD4F42913014Q34223822-3B1EF3D7-27BA-4D3B-91E8-C669F3E92707Q34249653-2F1D850C-CD4C-4B95-A1B8-A11560D13A14Q34296095-CA07D0A1-EAD0-40F1-A7AC-CADDD47E6321Q34356904-3C841193-1B52-4AAC-A392-6503D39D6074
P2860
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The genotoxic potential of ret ...... ouse model of HSC gene therapy
@en
The genotoxic potential of ret ...... use model of HSC gene therapy.
@nl
type
label
The genotoxic potential of ret ...... ouse model of HSC gene therapy
@en
The genotoxic potential of ret ...... use model of HSC gene therapy.
@nl
prefLabel
The genotoxic potential of ret ...... ouse model of HSC gene therapy
@en
The genotoxic potential of ret ...... use model of HSC gene therapy.
@nl
P2093
P2860
P50
P356
P1476
The genotoxic potential of ret ...... ouse model of HSC gene therapy
@en
P2093
Clelia Di Serio
Cynthia C Bartholomae
Fabrizio Benedicenti
Francesca Sanvito
Lucia Sergi Sergi
Manfred Schmidt
Marco Ranzani
Maurilio Ponzoni
P2860
P304
P356
10.1172/JCI37630
P407
P577
2009-03-23T00:00:00Z