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Effective T helper cell responses against retroviruses: are all clonotypes equal?Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assemblyStructural basis of evasion of cellular adaptive immunity by HIV-1 NefStructural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibodyMolecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor NefIntrinsic cellular defenses against human immunodeficiency virusesExogenous HIV-1 Nef upsets the IFN-γ-induced impairment of human intestinal epithelial integrityHydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis.Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee hostInefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infectionA flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells.SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.Link between primate lentiviral coreceptor usage and Nef function.Self-association of the Lentivirus protein, NefHIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation.The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentivirusesBrain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteinsNef proteins from simian immunodeficiency viruses are tetherin antagonists.The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference.Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier.Lentiviral Nef proteins manipulate T cells in a subset-specific mannerMisdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression.Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins.HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity.Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infectionHIV-induced immune activation: pathogenesis and clinical relevance - summary of a workshop organized by the German AIDS Society (DAIG e.v.) and the ICH Hamburg, Hamburg, Germany, November 22, 2008Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques.Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.HIV-1 Nef: at the crossroadsConservation of Nef function across highly diverse lineages of SIVsmm.Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections.Mechanisms of HIV-1 Nef function and intracellular signaling.The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.The adaptor protein SLP-76 regulates HIV-1 release and cell-to-cell transmission in T cells.Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Role of Nef in primate lentiviral immunopathogenesis.
@en
Role of Nef in primate lentiviral immunopathogenesis.
@nl
type
label
Role of Nef in primate lentiviral immunopathogenesis.
@en
Role of Nef in primate lentiviral immunopathogenesis.
@nl
prefLabel
Role of Nef in primate lentiviral immunopathogenesis.
@en
Role of Nef in primate lentiviral immunopathogenesis.
@nl
P2093
P1476
Role of Nef in primate lentiviral immunopathogenesis.
@en
P2093
P2888
P304
P356
10.1007/S00018-008-8094-2
P577
2008-09-01T00:00:00Z