Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesOverexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levelsA New Tessera into the Interactome of the isc Operon: A Novel Interaction between HscB and IscSStructural, Mechanistic and Coordination Chemistry of Relevance to the Biosynthesis of Iron-Sulfur and Related Iron CofactorsThe in vivo mitochondrial two-step maturation of human frataxin.Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge regionFrataxin and mitochondrial FeS cluster biogenesis.Molecular details of the yeast frataxin-Isu1 interaction during mitochondrial Fe-S cluster assemblyTORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's AtaxiaExtension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat.Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis.NMR assignments of a stable processing intermediate of human frataxin.Iron chaperones for mitochondrial Fe-S cluster biosynthesis and ferritin iron storageKey players and their role during mitochondrial iron-sulfur cluster biosynthesisFrataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe-S Assembly ComplexφXANES: In vivo imaging of metal-protein coordination environments.Iron binding activity is essential for the function of IscA in iron-sulphur cluster biogenesisHis86 from the N-terminus of frataxin coordinates iron and is required for Fe-S cluster synthesis.Frataxin directly stimulates mitochondrial cysteine desulfurase by exposing substrate-binding sites, and a mutant Fe-S cluster scaffold protein with frataxin-bypassing ability acts similarlyMetal acquisition and availability in the mitochondria.Assembly of the iron-binding protein frataxin in Saccharomyces cerevisiae responds to dynamic changes in mitochondrial iron influx and stress level.In vitro characterization of a novel Isu homologue from Drosophila melanogaster for de novo FeS-cluster formation.Methylene blue rescues heart defects in a Drosophila model of Friedreich's ataxia.Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe-S cluster assembly centers.Overexpression of Drosophila frataxin triggers cell death in an iron-dependent manner.Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism.Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly.Drosophila melanogaster Models of Friedreich's Ataxia.NMR as a Tool to Investigate the Processes of Mitochondrial and Cytosolic Iron-Sulfur Cluster Biosynthesis
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Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 June 2008
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vedecký článok
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vetenskaplig artikel
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name
Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
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Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
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Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
@en
Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
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prefLabel
Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
@en
Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
@nl
P2093
P2860
P356
P1433
P1476
Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.
@en
P2093
Andrew Dancis
Kalyan C Kondapalli
Nicole M Kok
Timothy L Stemmler
P2860
P304
P356
10.1021/BI800366D
P407
P577
2008-06-10T00:00:00Z