Peptide nucleic acid (PNA) binding and its effect on in vitro transcription in friedreich's ataxia triplet repeats.
about
Friedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.PNA binding to the non-template DNA strand interferes with transcription, suggesting a blockage mechanism mediated by R-loop formation.Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region24 Interference of PNA binding to the non-template strand with transcription supports the general model for transcription blockage by R-loop formation.Molecular therapy in myotonic dystrophy: focus on RNA gain-of-function.Bifacial PNA complexation inhibits enzymatic access to DNA and RNA.A novel mode for transcription inhibition mediated by PNA-induced R-loops with a model in vitro system.
P2860
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P2860
Peptide nucleic acid (PNA) binding and its effect on in vitro transcription in friedreich's ataxia triplet repeats.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Peptide nucleic acid (PNA) bin ...... eich's ataxia triplet repeats.
@en
type
label
Peptide nucleic acid (PNA) bin ...... eich's ataxia triplet repeats.
@en
prefLabel
Peptide nucleic acid (PNA) bin ...... eich's ataxia triplet repeats.
@en
P2093
P2860
P356
P1476
Peptide nucleic acid (PNA) bin ...... eich's ataxia triplet repeats.
@en
P2093
Boris P Belotserkovskii
Philip C Hanawalt
Richard Liu
P2860
P304
P356
10.1002/MC.20486
P577
2009-04-01T00:00:00Z