Mouse models of human AML accurately predict chemotherapy response - Wikidata - wikimedia - TriplyDB

Mouse models of human AML accurately predict chemotherapy response

Mouse models of human AML accurately predict chemotherapy response

http://www.wikidata.org/entity/Q37152257

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Animal models of leukemia: any closer to the real thing?The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53 Chd5 requires PHD-mediated histone 3 binding for tumor suppression RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia Death on the slopes. Symposium on Cell Death Pathways.Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia.Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia.The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia.AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth.Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.The genomic landscape of core-binding factor acute myeloid leukemias Guidelines for the welfare and use of animals in cancer research.Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice Towards patient-based cancer therapeutics.MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML.Targeting metastasis-initiating cells through the fatty acid receptor CD36.Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors Effects of iron depletion on CALM-AF10 leukemias.N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner.Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR MLL fusions: pathways to leukemia Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice.HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.

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Mouse models of human AML accurately predict chemotherapy response

http://www.wikidata.org/entity/Q37152257

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Mouse models of human AML accurately predict chemotherapy response

@en

Mouse models of human AML accurately predict chemotherapy response.

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type

label

Mouse models of human AML accurately predict chemotherapy response

@en

Mouse models of human AML accurately predict chemotherapy response.

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prefLabel

Mouse models of human AML accurately predict chemotherapy response

@en

Mouse models of human AML accurately predict chemotherapy response.

@nl

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Genes & Development

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Mouse models of human AML accurately predict chemotherapy response

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Amy R Rappaport

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Ina Radtke

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James R Downing

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M Eileen Dolan

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Miao-Miao Yang

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Mila E McCurrach

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Scott C Kogan

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Scott W Lowe

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Weijun Luo

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Zhen Zhao

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Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data.

KEGG: Kyoto Encyclopedia of Genes and Genomes

Significance analysis of microarrays applied to the ionizing radiation response

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

DAVID: Database for Annotation, Visualization, and Integrated Discovery

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.

Surfing the p53 network

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

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877-889

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scholarly article

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10.1101/GAD.1771409

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7

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23

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Timothy S Pardee

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2009-04-01T00:00:00Z

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24251372

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19339691

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2666344

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