Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.
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Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisIodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis InhibitorsToward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †Structural Alterations within Native Amyloidogenic Immunoglobulin Light ChainsAmyloidogenic Potential of Transthyretin Variants: INSIGHTS FROM STRUCTURAL AND COMPUTATIONAL ANALYSESA Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and CytotoxicityChemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasmaAromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent ConjugateTafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascadeStructural evidence for asymmetric ligand binding to transthyretinModulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsProbing conformational stability and dynamics of erythroid and nonerythroid spectrin: effects of urea and guanidine hydrochlorideA single mutation in an SH3 domain increases amyloid aggregation by accelerating nucleation, but not by destabilizing thermodynamically the native state.Transthyretin variants with improved inhibition of β-amyloid aggregation.Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases.Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidosesCharacterization of the interaction of β-amyloid with transthyretin monomers and tetramers.Quantification of quaternary structure stability in aggregation-prone proteins under physiological conditions: the transthyretin case.Recent progress in the understanding and treatment of transthyretin amyloidosis.Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission.Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversionEmergent properties of proteostasis in managing cystic fibrosis.TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons.Cooperative stabilization of transthyretin by clusterin and diflunisal.Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy.Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models.Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy).A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation.Targeting protein aggregation for the treatment of degenerative diseasesUncovering the Mechanism of Aggregation of Human Transthyretin.Localized structural fluctuations promote amyloidogenic conformations in transthyretin.Transthyretin as both a sensor and a scavenger of β-amyloid oligomersNovel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretinA current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures.The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology.Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro.The proteostasis boundary in misfolding diseases of membrane traffic.Quantification of transthyretin kinetic stability in human plasma using subunit exchange.Proteostasis strategies for restoring alpha1-antitrypsin deficiency.
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P2860
Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 June 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Quantification of the thermody ...... een stability and amyloidosis.
@en
Quantification of the thermody ...... een stability and amyloidosis.
@nl
type
label
Quantification of the thermody ...... een stability and amyloidosis.
@en
Quantification of the thermody ...... een stability and amyloidosis.
@nl
prefLabel
Quantification of the thermody ...... een stability and amyloidosis.
@en
Quantification of the thermody ...... een stability and amyloidosis.
@nl
P2860
P356
P1433
P1476
Quantification of the thermody ...... ween stability and amyloidosis
@en
P2093
Amy R Hurshman Babbes
P2860
P304
P356
10.1021/BI800636Q
P407
P577
2008-06-07T00:00:00Z