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mRNA splicing variants: exploiting modularity to outwit cancer therapy

mRNA splicing variants: exploiting modularity to outwit cancer therapy

http://www.wikidata.org/entity/Q37154455

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SpliceNet: recovering splicing isoform-specific differential gene networks from RNA-Seq data of normal and diseased samples.Methionyl-tRNA synthetase overexpression is associated with poor clinical outcomes in non-small cell lung cancer The role of mRNA splicing in prostate cancer.The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.Cloning of multiple ERα mRNA variants in killifish (Fundulus heteroclitus), and differential expression by tissue type, stage of reproduction, and estrogen exposure in fish from polluted and unpolluted environments.Alternative RNA structure-coupled gene regulations in tumorigenesis.Test-firing ammunition for spliceosome inhibition in cancer.Pre-mRNA splicing in cancer: the relevance in oncogenesis, treatment and drug resistance.Design and synthesis of analogues of natural products.Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ.Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer.The absence of a novel intron 19-retaining ALK transcript (ALK-I19) and MYCN amplification correlates with an excellent clinical outcome in neuroblastoma patients.

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mRNA splicing variants: exploiting modularity to outwit cancer therapy

http://www.wikidata.org/entity/Q37154455

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 22 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

mRNA splicing variants: exploiting modularity to outwit cancer therapy

@en

mRNA splicing variants: exploiting modularity to outwit cancer therapy.

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type

label

mRNA splicing variants: exploiting modularity to outwit cancer therapy

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mRNA splicing variants: exploiting modularity to outwit cancer therapy.

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prefLabel

mRNA splicing variants: exploiting modularity to outwit cancer therapy

@en

mRNA splicing variants: exploiting modularity to outwit cancer therapy.

@nl

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0008-5472.CAN-13-0444

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Cancer Research

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mRNA splicing variants: exploiting modularity to outwit cancer therapy

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Scott M Dehm

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P2860

Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis

The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.

Genetic therapies for RNA mis-splicing diseases

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

Landscape of transcription in human cells

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.

Silencing survivin splice variant 2B leads to antitumor activity in taxane--resistant ovarian cancer

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5309-5314

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scholarly article

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10.1158/0008-5472.CAN-13-0444

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2013-08-22T00:00:00Z

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3766449

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