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Addressing unmet medical needs in type 2 diabetes: a narrative review of drugs under developmentA potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.Label-Free Receptor Assays.Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.Molecular mechanisms underlying nutrient detection by incretin-secreting cells.Diabetes area participation analysis: a review of companies and targets described in the 2008 - 2010 patent literature.Glucose-dependent insulinotropic polypeptide: from pathophysiology to therapeutic opportunities in obesity-associated disorders.Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.Latest research and development trends in non-insulin anti-diabetics.Activation of GPR40 as a therapeutic target for the treatment of type 2 diabetes.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.Optimization of GPR40 Agonists for Type 2 Diabetes.Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors.
P2860
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P2860
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on May 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
GPR40: good cop, bad cop?
@en
GPR40: good cop, bad cop?
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type
label
GPR40: good cop, bad cop?
@en
GPR40: good cop, bad cop?
@nl
prefLabel
GPR40: good cop, bad cop?
@en
GPR40: good cop, bad cop?
@nl
P2860
P356
P1433
P1476
GPR40: good cop, bad cop?
@en
P2860
P304
P356
10.2337/DB09-0215
P407
P577
2009-05-01T00:00:00Z