Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.
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Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptorRole of bioactive fatty acids in nonalcoholic fatty liver diseaseMucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel DiseaseAn Acetate-Specific GPCR, FFAR2, Regulates Insulin SecretionThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsCommensal bacteria at the interface of host metabolism and the immune system.Perspectives on the therapeutic potential of short-chain fatty acid receptorsHuman Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell lineSCFA transport in rat duodenum.The role of short chain fatty acids in appetite regulation and energy homeostasis.Free fatty acid receptors: structural models and elucidation of ligand binding interactions.Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional BiasDrugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRsThe pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonismMinireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.The therapeutic potential of GPR43: a novel role in modulating metabolic health.Treatment of type 2 diabetes by free Fatty Acid receptor agonists.The Pharmacology and Function of Receptors for Short-Chain Fatty Acids.SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?FFAR3 modulates insulin secretion and global gene expression in mouse islets.Polymorphic Variation in FFA Receptors: Functions and Consequences.Key Questions for Translation of FFA Receptors: From Pharmacology to Medicines.Application of GPCR Structures for Modelling of Free Fatty Acid Receptors.FFA2 and FFA3 in Metabolic Regulation.The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment.Pharmacological properties of acid N-thiazolylamide FFA2 agonists.Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.Effect of surfactant hydrophobicity on the pathway for unfolding of ubiquitin.A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias.G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35.SCFAs strongly stimulate PYY production in human enteroendocrine cells.Ligands at the Free Fatty Acid Receptors 2/3 (GPR43/GPR41).G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets.Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease.Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1
P2860
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P2860
Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Extracellular ionic locks dete ...... acid receptors FFA2 and FFA3.
@en
type
label
Extracellular ionic locks dete ...... acid receptors FFA2 and FFA3.
@en
prefLabel
Extracellular ionic locks dete ...... acid receptors FFA2 and FFA3.
@en
P2093
P2860
P356
P1476
Extracellular ionic locks dete ...... acid receptors FFA2 and FFA3.
@en
P2093
Graeme Milligan
Irina G Tikhonova
Sunil K Pandey
P2860
P304
41195-41209
P356
10.1074/JBC.M112.396259
P407
P577
2012-10-12T00:00:00Z