Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer.
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Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDFUp-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cellsCellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal CancermiR-146a suppresses invasion of pancreatic cancer cells3, 3'-Diindolylmethane enhances the effectiveness of herceptin against HER-2/neu-expressing breast cancer cells3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing.Cancer stem cells: a novel paradigm for cancer prevention and treatment.MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function3,3'-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutantsAttenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic.Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells.Chemoprevention strategies for pancreatic cancerUp-regulation of miR-146a contributes to the inhibition of invasion of pancreatic cancer cells.The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy: Targeting Cellular Signaling, MicroRNAs, and Epigenome.A novel benzothiazole derivative YLT322 induces apoptosis via the mitochondrial apoptosis pathway in vitro with anti-tumor activity in solid malignancies.Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growthConcurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer.Small-molecule inhibitor of Bcl-2 (TW-37) suppresses growth and enhances cisplatin-induced apoptosis in ovarian cancer cells.Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors.Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo.Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer.Antioxidant function of isoflavone and 3,3'-diindolylmethane: are they important for cancer prevention and therapy?Anti-cancer drug 3,3'-diindolylmethane activates Wnt4 signaling to enhance gastric cancer cell stemness and tumorigenesis.Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cellsMechanisms and therapeutic implications of cell death induction by indole compounds.TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway.Down-regulation of miR-221 inhibits proliferation of pancreatic cancer cells through up-regulation of PTEN, p27(kip1), p57(kip2), and PUMA.RETRACTED: 3,3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer.Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics.PAR-4 as a possible new target for pancreatic cancer therapy.Dose-Dependent Responses of I3C and DIM on T-Cell Activation in the Human T Lymphocyte Jurkat Cell Line.Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs.Application of infrared-based molecular imaging to a mouse model with head and neck cancer.In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging.Enhanced cell growth inhibition by thiacremonone in paclitaxel-treated lung cancer cells.Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures.Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors.3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.Inhibitory effect of the low-toxic exogenous aryl hydrocarbon receptor modulator 3'3-diindolylmethane on gastric cancer in mice.
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P2860
Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Apoptosis-inducing effect of e ...... ic model of pancreatic cancer.
@en
Apoptosis-inducing effect of e ...... ic model of pancreatic cancer.
@nl
type
label
Apoptosis-inducing effect of e ...... ic model of pancreatic cancer.
@en
Apoptosis-inducing effect of e ...... ic model of pancreatic cancer.
@nl
prefLabel
Apoptosis-inducing effect of e ...... ic model of pancreatic cancer.
@en
Apoptosis-inducing effect of e ...... ic model of pancreatic cancer.
@nl
P2093
P2860
P1476
Apoptosis-inducing effect of e ...... ic model of pancreatic cancer.
@en
P2093
Aamir Ahmad
Bassel F El-Rayes
Fazlul H Sarkar
Philip A Philip
Sanjeev Banerjee
Shadan Ali
P2860
P304
P356
10.1158/1535-7163.MCT-08-0354
P577
2008-06-01T00:00:00Z