GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. - Wikidata - wikimedia - TriplyDB

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

http://www.wikidata.org/entity/Q37170811

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The endoplasmic reticulum stress response in aging and age-related diseases Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects Role of endoplasmic reticulum stress in drug-induced toxicity The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment Energy metabolism in the liver Xenobiotic perturbation of ER stress and the unfolded protein response Stress management: How the unfolded protein response impacts fatty liver disease Lipid biology of breast cancer Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish Chaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpression hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity Mechanisms for insulin resistance: common threads and missing links Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and management.Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) con The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance.Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity Pathogenesis of non-alcoholic fatty liver disease.ER stress and hepatic lipid metabolism.PGRN induces impaired insulin sensitivity and defective autophagy in hepatic insulin resistance Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish.Novel NBAS mutations and fever-related recurrent acute liver failure in Chinese children: a retrospective study Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection.Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.Regulation of basal cellular physiology by the homeostatic unfolded protein response Proteomic and genomic studies of non-alcoholic fatty liver disease--clues in the pathogenesis

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GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

http://www.wikidata.org/entity/Q37170811

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

GRP78 expression inhibits insu ...... ces hepatic steatosis in mice.

@en

GRP78 expression inhibits insu ...... ces hepatic steatosis in mice.

@nl

type

label

GRP78 expression inhibits insu ...... ces hepatic steatosis in mice.

@en

GRP78 expression inhibits insu ...... ces hepatic steatosis in mice.

@nl

prefLabel

GRP78 expression inhibits insu ...... ces hepatic steatosis in mice.

@en

GRP78 expression inhibits insu ...... ces hepatic steatosis in mice.

@nl

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Journal of Clinical Investigation

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GRP78 expression inhibits insu ...... ces hepatic steatosis in mice.

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Hervé Chabanon

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Hélène L Kammoun

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Isabelle Hainault

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Tatsuro Koike

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P2860

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

Signal integration in the endoplasmic reticulum unfolded protein response

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

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1201-1215

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scholarly article

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10.1172/JCI37007

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Fabienne Foufelle

Christophe Magnan

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2009-04-13T00:00:00Z

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19363290

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