Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
about
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasisTimosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stressMembrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseThe TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathwaysInsig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitroSterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytesThe sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavageMembrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorptionCREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBPProteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysinesThree mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cellsJuxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasisLiver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesisOverexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesisCholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responsesTwist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1cDiversity of degradation signals in the ubiquitin-proteasome systemInsig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosisSuppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profileCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepA conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAPInsig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytesCombined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesSterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to InsigCholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphilesDual functions of Insig proteins in cholesterol homeostasisUbiquitin ligases in cholesterol metabolismHydrogen peroxide sensing, signaling and regulation of transcription factorsThe combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescueNon-canonical progesterone signaling in granulosa cell functionConversion of psychological stress into cellular stress response: roles of the sigma-1 receptor in the processRules for the recognition of dilysine retrieval motifs by coatomerINSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteinsDynamics of hepatic and intestinal cholesterol and bile acid pathways: The impact of the animal model of estrogen deficiency and exercise trainingA lysosome-centered view of nutrient homeostasisA century of cholesterol and coronaries: from plaques to genes to statins
P2860
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P2860
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@ast
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@en
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@en-gb
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@nl
type
label
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@ast
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@en
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@en-gb
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@nl
prefLabel
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@ast
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@en
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@en-gb
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@nl
P2093
P50
P3181
P1433
P1476
Crucial step in cholesterol ho ...... ates retention of SREBPs in ER
@en
P2093
Michael E Wright
Michael S Brown
Peter J Espenshade
P304
P3181
P356
10.1016/S0092-8674(02)00872-3
P407
P577
2002-08-23T00:00:00Z