Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. - Wikidata - wikimedia - TriplyDB

Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.

Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.

http://www.wikidata.org/entity/Q37171127

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VE-statin/egfl7 expression in endothelial cells is regulated by a distal enhancer and a proximal promoter under the direct control of Erg and GATA-2 Fatty acid metabolism and the basis of brown adipose tissue function A role for phosphatidic acid in the formation of "supersized" lipid droplets Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes.Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay.What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health.Lysophosphatidic acid acyltransferase β (LPAATβ) promotes the tumor growth of human osteosarcoma.Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms Genetic control of de novo lipogenesis: role in diet-induced obesity Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers.Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes.Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria.Genetic determinants of hepatic steatosis in man.Glycerophosphate/Acylglycerophosphate acyltransferases.Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice.Targeting adipose tissue via systemic gene therapy Lipodystrophy: pathophysiology and advances in treatment Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling The Transcriptional Effects of PCB118 and PCB153 on the Liver, Adipose Tissue, Muscle and Colon of Mice: Highlighting of Glut4 and Lipin1 as Main Target Genes for PCB Induced Metabolic Disorders Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Pathways regulated by glucocorticoids in omental and subcutaneous human adipose tissues: a microarray study Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance.Seipin: from human disease to molecular mechanism Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals.Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice.Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure.Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.

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Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.

http://www.wikidata.org/entity/Q37171127

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on February 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Molecular mechanisms of hepati ...... tal generalized lipodystrophy.

@en

Molecular mechanisms of hepati ...... tal generalized lipodystrophy.

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type

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Molecular mechanisms of hepati ...... tal generalized lipodystrophy.

@en

Molecular mechanisms of hepati ...... tal generalized lipodystrophy.

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prefLabel

Molecular mechanisms of hepati ...... tal generalized lipodystrophy.

@en

Molecular mechanisms of hepati ...... tal generalized lipodystrophy.

@nl

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J.CMET.2009.01.002

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Cell Metabolism

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Molecular mechanisms of hepati ...... tal generalized lipodystrophy.

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Abhimanyu Garg

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Amy R Smith

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Anil K Agarwal

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David E Curtis

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Jay D Horton

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Jimin Ren

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Robert E Hammer

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Shirya Rashid

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Suja Sukumaran

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Victoria Esser

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P2860

Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway

A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase

Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells

Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

Roles of phosphatidate phosphatase enzymes in lipid metabolism

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

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10.1016/J.CMET.2009.01.002

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