Knock-out mouse models of proprotein convertases: unique functions or redundancy?
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Novel Furin Inhibitors with Potent Anti-infectious ActivityDisruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functionsZebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration.The role of furin in papillomavirus infection.Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cellsWhat lies ahead for the proprotein convertases?High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.Proprotein convertase inhibition: Paralyzing the cell's master switches.Generation and characterization of non-competitive furin-inhibiting nanobodies.Peptide processing and biology in human disease.Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications.Therapeutic uses of furin and its inhibitors: a patent review.The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif.Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation.Protective role of systemic furin in immune response-induced arthritis.Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesityThe PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol.The proprotein convertase PC7: unique zymogen activation and trafficking pathways.Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.Zymogen activation of neurotrypsin and neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans.Diagnostic utility of BNP, corin and furin as biomarkers for cardiovascular complications in type 2 diabetes mellitus patients.My road to Damascus: how I converted to the prohormone theory and the proprotein convertases.Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice.
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Knock-out mouse models of proprotein convertases: unique functions or redundancy?
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on May 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
@en
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
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type
label
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
@en
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
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prefLabel
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
@en
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
@nl
P356
P1476
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
@en
P2093
Abdel-Majid Khatib
John W M Creemers
P304
P356
10.2741/3055
P577
2008-05-01T00:00:00Z